Summary
A double-blind cross-over study was performed in 12 healthy female volunteers comparing cetirizine di-HCl (10 mg) and sustained release dexchlorpheniramine maleate (6 mg) with respect to attentuation of histamine-induced skin wheals and subjective central nervous system (CNS) effects. Cetirizine was significantly more effective than dexchlorpheniramine in suppressing the size of wheals from 2 to 24 h after drug administration. In fact, at 24 h cetirizine was still as affective as 2 h after ingestion. Ten subjects receiving dexchlorpheniramine reported subjective symptoms relating to CNS depression, in contrast to only one subject given cetirizine.
References
De Vos C, Maleux MR, Baltes E, Gobert J (1985) Inhibition of histamine skin reaction in four animal species by UCB PO71 (Cetirizine 2HCl). Ann Allergy 55 (part II): 392
Rihoux JP, de Vos C, Baltes E, Delaunoy J (1985) Pharmacoclinical investigation of cetirizine, a new potent and well tolerated anti-Hl1. Ann Allergy 55 (part II): 392
Fadel R, Herpin-Richard N, Rihoux JP, Henocq E (1987) Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo. Clin Allergy 17: 374–379
Harvey RP, Schocket AL (1980) The effect of H1 and H2 blockade on cutaneous histamine response in man. J Allergy Clin Immunol 65: 136–139
Moser L, Hüther KJ, Koch-Weser J, Lundt PV (1978) Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings. Eur J Clin Pharmacol 14: 417–423
Kulshrestha VK, Gupta PP, Turner P, Wadsworth J (1978) Some clinical pharmacological studies with terfenadine, a new antihistamine drug. Br J Clin Pharmacol 6: 25–29
Levander S, Hägermark O, Stahle M (1985) Peripheral antihistamine and central sedative effect of three H1-receptor antagonists. Eur J Clin Pharmacol 28: 523–529
Rihoux JP, Dupont P (1987) Comparative study of the peripheral and central effect of terfenadine and cetirizine 2HCl. Ann Allergy 59: 235–238
Phillips MJ, Meyrick Thomas RH, Moodley I, Davies RJ (1983) A comparison of the in vivo effects of ketotifen, clemastine, chlorpheniramine and sodium cromoglycate on histamine and allergen induced wheals in human skin. Br J Clin Pharmacol 15: 277–286
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Müller, F.O., Botha, J.J., van Dyk, M. et al. Attenuation of cutaneous reactivity to histamine by cetirizine and dexchlorpheniramine. Eur J Clin Pharmacol 35, 319–321 (1988). https://doi.org/10.1007/BF00558272
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00558272