Summary
A type of endocrine-like cell displaying all morphological features of protein secreting cells, has been found in the antro-pyloric mucosa of the stomach of mammals. Light and electron microscopy observations provide a sharp distinction of this cell from the 5-hydroxytryptamine-storing enterochromaffin cell. Its possible involvement in the secretion of a protein or peptide hormone is discussed.
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References
Bentley, P. H., G. W. Kumar, and R. C. Sheppard: Structures of human gastrins I and II. Nature (Lond.) 209, 583–585 (1966).
Caramia, F., B. Munger, and P. E. Lacy: The ultrastructural basis for the identification of cell types in the pancreatic islets. I. Guinea pig. Z. Zellforsch. 67, 533–546, (1965).
Cavallero, C., and E. Solcia: Cytological and cytochemical aspects of islet pathology in the Zollinger-Ellison syndrome. Rev. internat. Hépat. 15, 517–526 (1965).
— —, and R. Sampietro: Cytology of islet tumours and hyperplasias associated with the Zollinger-Ellison syndrome. Gut 8, 172–177 (1967).
Erspamer, V.: Il sistema cellulare enterocromaffine ed i suoi rapporti con il sistema insulare. Z. Anat. Entwickl.-Gesch. 109, 586–608 (1939).
—, and B. Asero: Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine. Nature (Lond.) 169, 800–801 (1952).
Falck, B., and B. Hellman: A fluorescent reaction for monoamines in the insulin producing cells of the guinea-pig. Acta Endocr. (KM.) 45, 133–138 (1964).
—, B. Larson, C. V. Mecklenburg, E. Rosenberg, and K. Svenaeus: On the presence of a second specific cell system in mammalian thyroid gland. Acta physiol. scand. 62, 491–492 (1964).
Feldberg, W., and C. C. Toh: Distribution of 5-hydroxytryptamine (serotonin, enteramine) in the wall of the digestive tract. J. Physiol. (Lond.) 119, 352–362 (1953).
Feyrter, F.: Über die peripheren endokrinen (parakrinen) Drüsen des Menschen. Wien: Wilhelm Maudrich 1953.
Gregory, H., P. M. Hardy, D. S. Jones, G. W. Kenner, and R. C. Sheppard: The antral hormone gastrin: structure of gastrin. Nature (Lond.) 204, 931–934 (1964).
Gregory, R. A.: Secretory mechanisms of the gastrointestinal tract. London: E. Arnold 1962.
—, and H. J. Tracy: The constitution and properties of two gastrins extracted from hog antral mucosa. Gut 5, 103–114 (1964).
Grimelius, L.: A modified silver protein method for studying the argyrophil cells of the islets of Langerhans. In: Brolin, S. E., B. Hellman, and H. Knutson, eds.: The structure and metabolism of the pancreatic islets, p. 99–103. London: Pergamon Press 1964.
Hamperl, H.: Über argyrophile Zellen. Virchows Arch. path. Anat. 321, 482–507 (1952).
Helander, H. F.: Ultrastructure of fundus glands of the mouse gastric mucosa. J. Ultrastructure Research, Suppl. 4, 7–123 (1962).
—: Ultrastructure of secretory cells in the pyloric gland area of the mouse gastric mucosa. J. Ultrastructure Research 10, 145–159 (1964).
Hellerström, C., and B. Hellman: Some aspects of silver impregnation of the islets of Langerhans in the rat. Acta Endocr. (Kbh.) 35, 518–532 (1960).
Holcenberg, J., and E. P. Benditt: A new color reaction for tryptamine derivatives. Histochemical application to enterochromaffin cells. Lab. Invest. 10, 144–158 (1961).
Ito, S., and R. J. Winchester: The fine structure of the gastric mucosa in the bat. J. Cell Biol. 16, 541–577 (1963).
Kurosumi, K., S. Shibasaki, G. Uchida, and Y. Tanaka: Electron microscope studies on the gastric mucosa of normal rats. Arch. Histol. (Jap.) 15, 587–598 (1958).
McManus, J. F. A., and R. W. Mowry: Staining methods. New York: P. B. Hoeber 1960.
Potet, F., E. Martin, J. P. Thiery, J. P. Bader, S. Bonfils, and A. Lambling: Etude histologique et cytologique du pancréas endocrine, tumoral et non tumoral dans le syndrome de Zollinger-Ellison. Rev. int. Hépat. 16, 737–761 (1966).
Ratzenhofer, M., und D. Leb: Über die Feinstruktur der Argentaffinen und der anderen Erscheinungsformen der „Hellen Zellen“ Feyrter's im Kaninchen-Magen. Z. Zellforsch. 67, 113–150 (1965).
Solcia, E., and G. Bertoli: Studio citologico di un tumore insulare con sindrome di Zollinger-Ellison. Boll. Soc. ital. Pat. 8, 229–232 (1964).
—, and R. Sampietro: Osservazioni sulla basofilia delle cellule argentofile e di quelle enterocromaffini. Riv. Istoch. norm. pat., 9, 265–278 (1965a).
— —: Cytologie observations on pancreatic islets with reference to some endocrine-like cells of the gastrointestinal mucosa. Z. Zellforsch. 68, 689–698 (1965b).
— —: Indole nature of enterochromaffin substance. Nature (Lond.) 214, 196–197 (1967a).
- - New methods for staining secretory granules and 5-hydroxytryptamine in the thyroid “C” cells. Symposium on thyrocalcitonin and the C cells, London (1967 b; in press).
— —, and G. Vassallo: Indole reactions of enterochromaffin cells and mast cells. J. Histochem. Cytochem. 14, 691–692 (1966a).
— — —: Distribuzione della 5-idrossitripttamina nei mastociti. Boll. Soc. ital. Pat. 9, 189–191 (1966b).
- G. Vassallo, and R. Sampietro: Unpublished results (1967).
Tauber, S., and L. L. Madison: The isolation and characterization of porcine gastrin. J. biol. Chem. 240, 645–650 (1965).
Toner, P. G.: Fine structure of argyrophil and argentaffin cells in the gastro-intestinal tract of the fowl. Z. Zellforsch. 63, 830–839 (1964).
Vialli, M.: Considerazioni su alcuni problemi ancora aperti nello studio delle cellule enterocromaffini. Rend. Ist. Lombardo Sci. Lett., Cl. Sci. (B) 97, 267–290 (1963).
—: Histology of the enterochromaffin cell system. In: V. Erspamer, ed. — 5-Hydroxytryptamine and related indolealkylamines, p. 1–65. Handbuch der experimentellen Pharmakologie, Bd. XIX. Berlin-Heidelberg-New York: Springer 1966.
—, and V. Erspamer: Considerazioni sul sistema enterocromaffine (a proposito di una recente monografia di Feyrter). Z. Zellforsch. 29, 487–501 (1939).
— —: Sulle reazioni chimiche colorate dell'enteramina. I. Ricerche su estratti acetonici di mucosa gastro-intestinale. Arch. Sci. Biol. (Bologna) 28, 101–121 (1942).
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This investigation was supported by grant N. 115/1139/991 from the Italian Consiglio Nazionale delle Ricerche.
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Solcia, E., Vassallo, G. & Sampietro, R. Endocrine cells in the antro-pyloric mucosa of the stomach. Z.Zellforsch 81, 474–486 (1967). https://doi.org/10.1007/BF00541009
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DOI: https://doi.org/10.1007/BF00541009