Summary
The authors discuss which type of antibodies, the circulating or the tissue-bound antibodies, are important in the pathogenesis of fixed drug eruptions (FAE). Observation of some pertinent cases and results of epicutaneous tests support the hypothesis that in FDE the tissue-bound antibodies are of main importance.
Histologic examinations of different stages of FDE are rather indicative of the antigen-antibody reaction taking place in the cutis, not in the epidermis.
Zusammenfassung
Es wurde der Typ der Antikörper, ob zirkulierende oder gewebsgebundene, erörtert. Die Beobachtungen einiger besonderer Fälle und die Ergebnisse der Epicutantestung sprechen dafür, daß beim FAE gewebsgebundene Antikörper die Hauptrolle spielen.
Die histologischen Untersuchungen — in den zeitlich verschiedenen Stadien des FAE durchgeführt — sprechen eher dafür, daß die Antigen-Antikörper-Reaktion in der Cutis und nicht in der Epidermis stattfindet.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Abe, Masao: Fixed drug eruption. Jap. J. Derm. 62, 18 (1952).
: Drug eruptions, particulary fixed eruptions. −2, Clinical observation. Jap. J. Derm. 63, 74 (1953).
Apolant, H.: Die Antipyrinexantheme. Arch. Derm. Syph. (Berl.) 46, 345 (1898).
: Zur Pathogenese der localisierten Antipyrinexantheme. Derm. Z. 6, 67 (1899).
Cannon, A. B.: Dermatitis medicamentosa (Phenolphthalein). Case presentation. Arch. Derm. Syph. (Chic.) 24, 899 (1931).
Chargin, L.: Phenobarbital (Luminal) eruption on tongue, cheeks and lips. Arch. Derm. Syph. (Chic.) 6, 222 (1922).
: Fixed eruption due to Arsphenamine. Case presentation. Arch. Derm. Syph. (Chic.) 37, 144 (1938).
: Fixed eruption in a patient sensitive to Arsphenamine and Phenolphthalein in different areas. Case presentation. Arch. Derm. Syph. (Chic.) 38, 474 (1938).
, and W. Leifer: Fixed eruptions produced by the Arsphenamines. J. invest. Derm. 3, 443 (1940).
Goodman, M. H., and R. D. Arthur: Fixed eruptions. Report of an unusual condition due to Sulfanilamide. Arch. Derm. Syph. (Chic.) 43, 692 (1941).
Knowless, F. C., H. B. Decker, and R. P. Kandle: Phenophthalein dermatitis. An experimental study including reproduction of the eruption in skin transplant. Arch. Derm. Syph. (Chic.) 33, 227 (1936).
Loveman, A. B.: Experimental aspect of fixed eruption due to Alurate, a compound of Allonal. J. Amer. med. Ass. 102, 97 (1934).
, and F. A. Simon: Fixed eruption and stomatitis due to Sulfanilamide. Arch. Derm. Syph. (Chic.) 40, 29 (1939).
Novy, F. G., jr.: Drug eruptions due to Barbiturates. Calif. west. Med. 49, 324 (1938).
Stritzler, C., and A. W. Kopf: Fixed drug eruption caused by 8-Chlorotheophyl-line in Dramamine with clinical and histologic studies. J. invest. Derm. 34, 319 (1960).
Urbach, E.: zit. von Minoru Yamada.
Welsh, A. L.: zit. von The fixed eruption. — A possible hazard of modern drug therapy. Springfield, Ill. Ch. C. Thomas 1961.
Wise, F.: zit. von Minoru Yamada.
, and E. W. Abramowitz: Phenolphthalein eruptions. Arch. Derm. Syph. (Chic.) 5, 297 (1922).
, and M. B. Sulzberger: Drug eruptions. — 1. Fixed Phenolphthalein eruptions. Arch. Derm. Syph. (Chic.) 27, 549 (1933).
Yamada, Minoru: Study on fixed drug eruption. Jap. J. Derm. 68, 960 (1958).
Author information
Authors and Affiliations
Additional information
Herrn Prof. Dr. A. Wiedmann zum 65. Geburtstag gewidmet.
Rights and permissions
About this article
Cite this article
Furuya, T., Sekido, N. & Ishihara, F. Beitrag zum fixen Arzneimittelexanthem. Arch. klin. exp. Derm. 225, 375–383 (1966). https://doi.org/10.1007/BF00521129
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00521129