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Changes of trace element concentrations of human tissues and body fluids due to therapeutic and diagnostic treatment

Veränderungen der Spurenelement-Konzentrationen in menschlichen Geweben und Körperflüssigkeiten als Folge von therapeutischen und diagnostischen Maßnahmen

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Zusammenfassung

Für mehr als 30 Spurenelemente werden die normalen Konzentrationen in menschlichen Geweben und Körperflüssigkeiten durch medizinische Behandlung verändert. In dieser Arbeit wird ein Überblick gegeben über derartige Effekte, die zugrundeliegenden Mechanismen und die medizinischen Implikationen. Letztere reichen von pathologischen Mangelerscheinungen bis zu schwersten Vergiftungen. Darüber hinaus können sie Langzeitveränderungen des Spurenelementhaushaltes bewirken, deren Konsequenzen derzeit noch nicht abgeschätzt werden können. Veränderungen der Spurenelementkonzentrationen durch therapeutische Maßnahmen werden beobachtet bei intensiver medizinischer Behandlung, als Folge von Medikation und bei Anwendung von Implantaten. Sie treten aber auch bei medizinischer und normaler Körper- und Hautpflege und als Folge sog. gesunder Lebensführung auf. Diagnostische Maßnahmen, die im allgemeinen keine medizinischen Implikationen nach sich ziehen, können die Spurenelementzusammensetzung von Geweben und Körperflüssigkeiten extrem verändern durch Wechselwirkung des Probenmaterials mit Medikamenten und Materialien, die während diagnostischer Eingriffe verwendet werden. Alle diese Effekte belegen, daß die Spurenelementanalyse normaler menschlicher Gewebe durch medizinische Behandlung beeinflußt wird und daß diese Ursache für Variationen normaler Spurenelementkonzentrationen stärker als bisher in Rechnung gestellt werden muß.

Summary

The normal levels of more than 30 trace elements in human tissues and body fluids are changed as a consequence of medical treatments. In this work, a survey is given on the occurrences of such effects, the acting mechanisms and the medical implications, the latter ranging from pathological signs of deficiency to severe intoxications. Moreover, they can cause long-term disturbances of the trace element balance, the consequences of which cannot even be estimated up to now. The changes of trace element levels by therapeutic treatment originate from intense medical treatment, from medication, from medical implants, as well as from medical and everydays body and skin care and from the so-called healthy style of living. Also diagnostic treatment which mostly has no medical implications can strongly alter the trace element composition of tissues and body fluids by interaction of the samples with medicaments and materials used during diagnostic interventions. All these effects demonstrate that the investigation of normal human tissues can be heavily biased by medical treatment and that this source of variability of trace elements has to be properly taken into account.

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    Rolf Michel

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Dedicated to Prof. Dr. W. Fresenius on the occasion of his 70th birthday

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Michel, R. Changes of trace element concentrations of human tissues and body fluids due to therapeutic and diagnostic treatment. Z. Anal. Chem. 317, 451–460 (1984). https://doi.org/10.1007/BF00494515

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