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1,5-Benzodiazepines (review)

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Methods for the synthesis of and the most important properties of 1,5-benzodiazepines are examined. The specifications of models of pharmacological significance are briefly given.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, USSR

    Z. F. Solomko & A. N. Kost

  2. Dnepropetrovsk State University, Deutschland

    Z. F. Solomko & A. N. Kost

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1443–1463, November, 1975.

A number of interesting papers, the citations to which we have included only selectively, were published after the text of this review had been prepared for printing. A small review by Lloyd and Cleghorn [282] encompassing 53 publications and in which one can find data on the physicochemical study of the described models appeared in 1974. We felt it useful to supplement our text with citations to studies of the biological activity of 1,5-benzodiazepines (see [283–290]) and of several condensed structures including a 1,5-benzodiazepine fragment or a fragment of its heterocyclic analogs (see [291–306]). The authors thank Dr. K. H. Weber for sending us the text of the plenary paper that he presented in Czechoslovakia [274].

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Solomko, Z.F., Kost, A.N. 1,5-Benzodiazepines (review). Chem Heterocycl Compd 11, 1231–1248 (1975). https://doi.org/10.1007/BF00474444

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