Summary
Looking for the morphological correlation of uremic inner ear damage a 5/6 resection of kidney parenchyma in rats was performed. A biochemically proven chronic uremia was so created. The ultrastructural examination of the stria vascularis showed a marked swelling of the intermediate cells, compressing occasionally stria vessels. The stria was enlarged and the mitochondria of the dark and light cells swollen. In the spiral ligament connective tissue cells were moderately swollen and blood vessels partially obstructed by swelling of the endothelium.
These changes are proved not to be dependent on the urea. The pathophysiological significance for uremic inner ear damage can only be determined after further examination of cochlear tissue.
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Literatur
David, H., Hecht, A.: Submikroskopische Strukturveränderungen der Herzmuskelkapillaren im Infarktgebiet. Zbl. allg. Path. path. Anat. 103, 68–74 (1961)
Heitz, Ph., Meier, P., Riede, U. N.: Ultrastrukturell-morphometrische Veränderungen der Leberparenchymzelle der Ratte bei experimentellem chronischem urämischem Syndrom. Path. europ. Vol. 6, n∘ 4, 433–444 (1971)
Kikuchi, K., Hilding, D. A.: The spiral vessel and stria vascularis in Shaker-1 mice. Electron microscopic and histochemical observations. Acta oto-laryng. (Stockh.) 63, 395–410 (1967)
Kimura, R. S., Ota, C. Y.: Ultrastructure of the cochlear blood vessels. Acta oto-laryng. (Stockh.) 77, 231–250 (1974)
Kimura, R. S., Schuknecht, H. F.: The ultrastructure of the human stria vascularis. Part II. Acta otolaryng. (Stockh.) 70, 301–318 (1970)
Kopsa, H., Kotzaurek, R., Mitschke, H., Schmidt, P.: Hörstörungen bei chronischer Niereninsuffizienz. Mschr. Ohrenheilk. 106, 332–339 (1972)
Merck, W., Sparwald, E., Cürten, I.: Über den Einfluß verschiedener Fixationsmethoden und Fixationsmittel auf die elektronenmikroskopische Struktur der Stria vascularis, Prominentia spiralis und des Ligamentum spirale beim Meerschweinchen. Arch. Oto-Rhino-Laryng. 206, 299–310 (1974)
Millonig, G.: Further observations on a phosphate buffer for osmium solutions in fixation. 5th Internat. Congr. EM Philadelphia. Vol. 2, P-8 (1962)
Mitschke, H., Schmidt, P., Kopsa, H., Zazgornik, J.: Effekt der Nierentransplantation auf die urämische Hörstörung. Dtsch. med. Wschr. 98, 2445–2447 (1973)
Morrison, A. B.: Experimental chronic renal insufficiency. In: Bajusz, E., Jasmin, G.: Methods and achievements in experimental pathology. Vol. 1, pp. 455–475. Basel-New York: Karger 1966
Platt, R., Roscoe, M. H., Smith, F. W.: Experimental renal failure. Clin. Sci. 11, 217–231 (1952)
Rodriguez-Echandia, E. L., Burgos, M. H.: The fine structure of the stria vascularis of the guinea-pig inner ear. Z. Zellforsch. 67, 600–619 (1965)
Spoendlin, H.: Auditory, vestibular, olfactory and gustatory organs, pp. 173–337. In: Babel, J., Bischoff, A., Spoendlin, H.: Ultrastructure of the peripheral nervous system and sense organs. Atlas of normal and pathologic anatomy. Stuttgart: Thieme 1970
Yassin, A., Safwat, F., Fatt-Hi, A.: Ear, nose and throat manifestations in cases of renal failure treated by dialysis, hemodialysis and peritoneal dialysis. Ann. Otol. (St. Louis) 75, 192–201 (1966)
Yassin, A., Badry, A., Fatt-Hi, A.: The relationship between electrolyte balance and cochlear disturbances in cases of renal failure. J. Laryng. 84, 429–435 (1970)
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Die Autoren danken Herrn Priv. Doz. Dr. U. N. Riede, Pathologisches Institut der Universität Freiburg i. Br., für die freundliche Beratung bei der Auswertung der Befunde.
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Merck, W., Hoppe-Seyler, G. & Cürten, I. Ultrastrukturelle Veränderungen an der Stria vascularis und dem Ligamentum spirale bei chronisch-urämischen Ratten. Arch Otorhinolaryngol 214, 63–70 (1976). https://doi.org/10.1007/BF00455109
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DOI: https://doi.org/10.1007/BF00455109