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Morphologische Untersuchungen zur Toxizität der Ethacrynsäure an der Prominentia spiralis

Morphological investigations on the toxicity of ethacrynic acid in the spiral prominence

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Summary

Ultrastructural changes in the guinea pig spiral prominence were studied at various times after a single intravenous injection of ethacrynic acid (40 mg/kg body-weight). Initial swelling of endolymph-facing epithelial cells was followed by dilatation of the intercellular spaces and marked shrinkage of the stroma cells surrounding the spiral prominence vessel. While the changes in the stria vascularis and the spiral prominence progressed at about the same pace, the regression to normal ultrastructure set in earlier in the spiral prominence.

Zusammenfassung

Nach einmaliger intravenöser Ethacrynsäure-Applikation (40 mg/kg Körpergewicht) wurden die ultastrukturellen Veränderungen in der Prominentia spiralis der Meerschweinchenschnecke nach Einwirkungszeiten zwischen 5 und 90 min untersucht.

Nach einer initialen Schwellung der den Endolymphraum begrenzenden Epithelzellen entwickelte sich ein interzelluläres Ödem und eine ausgeprägte Schrumpfung der das Vas prominens umgebenden Stromazellen mit nachfolgender Erweiterung des Perivascularraumes.

Während die Veränderungen in der Stria vascularis und der Prominentia spiralis im zeitlichen Verlauf sich weitgehend identisch entwickelten, setzte die Rückbildung zur normalen Ultrastruktur in der Prominentia spiralis früher ein.

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Authors and Affiliations

  1. Klinikum Großhadern, Klinik und Poliklinik für Hals-Nasen-Ohrenkranke der Universität München, Marchioninistraße 15, D-8000, München 70, Bundesrepublik Deutschland

    K. Mees & W. Arnold

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  1. K. Mees
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  2. W. Arnold
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Mit Unterstützung der Deutschen Forschungsgemeinschaft

Für wertvolle technische Assistenz danken wir Frl. S. Linnenkohl und Herrn Ganea.

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Mees, K., Arnold, W. Morphologische Untersuchungen zur Toxizität der Ethacrynsäure an der Prominentia spiralis. Arch Otorhinolaryngol 236, 217–228 (1982). https://doi.org/10.1007/BF00454213

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  • DOI: https://doi.org/10.1007/BF00454213

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