Abstract
Twenty-three children with severe asthma who had been resident at high altitude for at least 3 months, considerably reduced their requirement for regular anti-asthma therapy. On a standard exercise challenge in low humidity, ten had no response, seven had isolated immediate bronchospasm and six had biphasic responses with immediate bronchospasm followed 4–10 h later by a late reaction sustained for at least 2h. The existence of biphasic responses after exercise, similar to those observed after antigen challenge, supports the concept of mast cell involvement in exercise-induced asthma.
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Abbreviations
- EIA:
-
exercise-induced asthma
- PEFR:
-
peak expiratory flow rate
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Boner, A., Niero, E., Antolini, I. et al. Biphasic (early and late) asthematic responses to exercise in children with severe asthma, resident at high altitude. Eur J Pediatr 144, 164–166 (1985). https://doi.org/10.1007/BF00451905
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DOI: https://doi.org/10.1007/BF00451905