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Concentration of cefuroxime in the bones of albino white rats: A comparative study of femur, humerus, and mandible

  • Clinical and Experimental Forum
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Summary

The levels of cefuroxime in rat bones with a different morphology, function, blood supply, and proportion between lamellar and cancellous bone were studied, after a 24-h administration of 750mg/kg × 3. The concentrations in the right and left femora, humeri, and mandibles of the same animal were measured 2 h after the last adminstiration. The result indicate statistically significant differences between femur and humerus (P < 0.001), femur and mandible (P < 0.05), and humerus and mandible (P < 0.05).

Zusammenfassung

Es wurde untersucht, ob Knochen mit verschiedener Morphologie, Funktion, Topographie, Blutversorgung und Kompakta-Spongiosa-Anteil, unterschiedliche Anreicherung von Cefuroxime zeigten. Hierfür wurde 750 mg/kg/8 h Cefuroxime i.m. bei 40 Ratten (Wistar) injiziert (insgesamt 3 ×). Zwei Stunden nach der letzten Medikation wurden nach Tötung der Tiere die Femora, Humeri und Mandibulae entfernt. Es ergaben sich statistische Unterschiede in den Antibiotikakonzentrationen zwischen Femur und Humerus (P0,001), Femur und Mandibula (P < 0,05) und Humerus und Mandibula (P < 0,05).

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References

  1. Daikos GK, Kosmidis J, Stathakis C, Anyfantis A, Plakoutsis T, Papathanasiou B (1977) Bioavailability of cefuroxime in various site including bile, sputum and bone. Proc R Soc Med 70:38–41

    Google Scholar 

  2. Dornbush V (1978) Antibiotics in bone tissues: methodological and practical aspects. Scand J Infect Dis 14:177–185

    Google Scholar 

  3. Dornbush K, Hugo H, Libstroem A (1980) Antibacterial activity of cefuroxime in human bone. Scand J Infect Dis 12:49–53

    Google Scholar 

  4. Hughes S, Robertson S, Susan W, Darrell J, Kennedy M, Dask CH (1980) Cefuroxime in bone. Royal Society of Medicine. International Congress and Symposium Series, No 38, pp 163–171

  5. Whitman DH, Schassan HH, Seidel H (1979) Study on the bioavailability of cefuroxime in bones and wound secretions. Med Welt 70:227–232

    Google Scholar 

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Authors and Affiliations

  1. Department of Experimental Pharmacology, Medical School, University of Athens, Greece

    J. Papadopulos, A. Patrikiou, C. Mandalenakis & C. Capri

  2. Department of Oral and Maxillofacial Surgery, Dental School, Athens, Greece

    J. Papadopulos, A. Patrikiou, C. Mandalenakis & C. Capri

Authors
  1. J. Papadopulos
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  2. A. Patrikiou
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  3. C. Mandalenakis
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  4. C. Capri
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Papadopulos, J., Patrikiou, A., Mandalenakis, C. et al. Concentration of cefuroxime in the bones of albino white rats: A comparative study of femur, humerus, and mandible. Arch. Orth. Traum. Surg. 105, 373–374 (1986). https://doi.org/10.1007/BF00449946

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  • DOI: https://doi.org/10.1007/BF00449946

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