Summary
Material from eight peptide hormone-secreting tumours, extirpated from the pancreas or from the antrum-duodenum region, was examined. Four of the patients had the clinical manifestations of the Zollinger-Ellison syndrome, two showed the features of an insulin-secreting tumour and one had a glucagonoma. Gastrin-producing cells, identified by immunohistochemistry, were found in five of the tumours. These cells displayed a varying degree of formaldehyde-ozone-induced fluorescence. This agrees with previous observations on the gastrin cell of human antral and duodenal mucosa. From model experiments, formaldehyde-ozone-induced fluorescence is thought to reflect the presence of peptides having tryptophan in the NH2-terminal position. The nature of this peptide in gastrin-producing cells is unknown.
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Grant support from Riksföreningen mot Cancer (806-874-01X) and J. and A. Persson's Foundation and the Swedish Medical Research Council (project No. 04X-1007, 04X-3764).
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Larsson, L.I., Sundler, F., Grimelius, L. et al. Formaldehyde-ozone-induced fluorescence in gastrin-producing tumours. Virchows Arch. A Path. Anat. and Histol. 365, 179–184 (1975). https://doi.org/10.1007/BF00434036
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DOI: https://doi.org/10.1007/BF00434036