Abstract
A vasopressin derivative or placebo was administered to 21 chronic schizophrenia patients for 3 weeks in a randomized crossover double-blind design. The patients were divided into those above and below the median on baseline memory measured by the Wechsler memory scale. Vasopressin treatment did not improve memory either in those patients with below median baseline memory or in the group as a whole.
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Boer GJ, Swaab HBM, Uylings K, Boer RM, Buijs RM, Vellis DN (1980) Neuropeptides in rat brain development. In: McConnell PS, Boer GJ, Romijn JH, Van de Poll NE, Corner MA (eds.) Progress in brain research vol. 53, Elsevier, North Holland, Biomedical Press, Amsterdam, pp 208–227
Forizs L (1952) Treatment of mental patients with antidiuretic hormone of the posterior pituitary. Dis Nerv Syst 13:44–47
Johnstone EC, Crow TJ, Frith CD, Husband J, Kreel L (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 2:924–926
Korsgaard S, Casey DE, Damgaard Pedersen NE, Jorgensen A, Gerlach J (1981) Vasopressin in anergic schizophrenia: A cross-over study with lysine-8-vasopressin and placebo. Psychopharmacology 74:379–382
Rigter H, Crabbe JC (1979) Modulation of memory by pituitary hormones and related peptides. Vitamins and Hormones 3:153–241
Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria: Rationale and reliability. Arch Gen Psychiatry 35:773–782
Vranckx C, Minne Ph, Benghezal A, Moeglen JM, Audibert A (1979) Vasopressin and schizophrenia. In: Obiols C, Ballus C, Gonzales-Monclus E, Pujol J (eds) Biological psychiatry today, Elsevier, North-Holland, Biomedical Press, pp 573–578
Weinberger DR, Fuller Torrey E, Neophytides AN, Wyatt RJ (1979) Lateral cerebral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry 36:735–739
Weingartner H, Gold P, Ballenger JC, Smallberg SA, Summers R, Rubinow DR, Post RM, Goodwin FK (1981) Effect of vasopressin on human memory function. Science 211:601–603
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Stein, D., Bannet, J., Averbuch, I. et al. Ineffectiveness of vasopressin in the treatment of memory impairment in chronic schizophrenia. Psychopharmacology 84, 566–568 (1984). https://doi.org/10.1007/BF00431468
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DOI: https://doi.org/10.1007/BF00431468