Summary
Gastric choriocarcinoma is a rare tumor and attracts interest because of its controversial pathogenesis. The present study reports a choriocarcinomatous change with immunocytochemically hCG-positive cells in the gastric carcinoma. The patients were males, one was 41 years old and the other 42 years old. The tumor of both cases consists of adenocarcinoma and choriocarcinoma. A sequential process of morphological transition of the adenocarcinoma to the choriocarcinoma can be traced. Indirect immunoperoxidase stain (PAP method) for human chorionic gonadotropin (hCG) demonstrates the localization of hCG in the syncytiotrophoblasts. Small number of cytotrophoblasts are weakly positive. None of the components of adenocarcinoma of both cases is positive for hCG. Human placental lactogen is not demonstrated in both cases. Stain for pregnancy specific β-1 glycoprotein is weakly positive in the adenocarcinoma of one case but not in the choriocarcinoma. In one case, the concentration of hCG was 19.9mIU/ml in the preoperative serum and decreased to 1.2mIU/ml after gastrectomy. HCG production by gastric carcinoma was discussed with regard to possible pathogenesis of gastric choriocarcinoma.
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References
Davidsohn C (1905) Chorion-Epitheliom und Magenkrebs, eine seltene Verschmelzung zweier bösartiger Geschwulste. Charité Ann 29:426–437
de Ikonicoff LK, Cedard L (1973) Localization of human chorionic gonadotropic and somatomammotropic hormones by the peroxidase immunohistoenzymologic method in villi and amniotic epithelium of human placentas. Am J Obstet Gynecol 116:1124–1132
Hartz PH, Ramirez CA (1953) Coexistence of carcinoma and chorioepithelioma in the stomach of a young man. Cancer 6:319–326
Haruma K, Takashima S, Suenaga K, Ide H, Moriwaki S (1980) Adenocarcinoma with chorionepitheliomatous change in the remnant stomach of a male adult, report of a case (in Japanese). Stomach Intestine 15:1235–1240
Hattori M, Yoshimoto Y, Matsukura S, Fujita T (1980) Qualitative and quantitative analyses of human chorionic gonadotropin and its subunits produced by malignant tumors. Cancer 46:355–361
Hayashi K, Motoi M, Tsutsumi A, Endo T (1981) Choriocarcinoma in the stomach of an adult male. Case report with a review of the literature on male subjects (in Japanese). Jpn J Cancer Clin 27:1654–1660
Jindrak K, Bochetto JF, Alpert LI (1976) Primary gastric choriocarcinoma: Case report with review of world literature. Hum Pathol 7:595–604
Kameya T, Shimosato Y, Tumuraya M, Ohsawa N, Nomura T (1976) Human gastric choriocarcinoma serially transplanted in nude mice. J Natl Cancer Inst 56:325–332
Kodama T, Kameya T, Hirota T, Shimosato Y, Ohkura H, Mukojima T, Kitaoka H (1981) Production of alpha-fetoprotein, normal serum proteins, and human chorionic gonadotropin in stomach cancer: Histologic and immunohistochemical analyses of 35 cases. Cancer 48:1647–1655
Koritschoner R (1920) Über ein Chorionepitheliom ohne Primärtumor mit abnorm langer Latenzzeit. Beitr Pathol Anat Allg Pathol 66:501–570
Kuwashima M, Nishimura M, Tsumura O, Sato H, Sekiguchi S, Iwata S, Kawaoi A, Kawano K, Tsuchiya T (1976) Ectopic gonadotropin production in gastric carcinoma. I. Urinary gonadotropin level and immunopathological findings (in Japanese). Jpn J Clin Pathol 24:737–741
Pick L (1926) Über die chorionepitheliomähnliche metastasierende Form des Magencarcinoms. Klin Wochenschr 5:1728–1729
Regan JF, Cremin JH (1960) Chorionepithelioma of the stomach. Am J Surg 100:224–232
Saigo PE, Brigati DJ, Sternberg SS, Rosen PP, Turnbull AD (1981) Primary gastric choriocarcinoma. An immunohistological study. Am J Surg Pathol 5:333–342
Sakauchi N, Chikada C, Nomura K, Mukojima T (1972) Choriocarcinoma probably of stomach origin and gastric carcinoma with immunological activity of hCG (in Japanese). Jpn J Cancer Clin 18:439–442
Smith FR, Barkin JS, Hensley G (1980) Choriocarcinoma of the stomach. Am J Gastroenterol 73:45–48
Sugiyama Y, Chiba M, Ino M, Kikuchi A, Yokouchi M (1977) Coexistence of chorionepithelioma and carcinoma in the stomach of a man. Case report and review of the literature in the male subject (in Japanese). Stomach Intestine 12:371–376
Tanaka S, Sakae K, Kato N (1972) Coexistence of chorionepithelioma and carcinoma in the stomach in the male adult: Report of four cases (in Japanese). Stomach Intestine 7:1369–1375
Uriel J (1976) Cancer, retrodifferentiation, and the myth of Faust. Cancer Res 36:4269–4275
Vaitukaitis JL (1974) Changing placental concentrations of human chorionic gonadotropin and its subunits during gestation. J Clin Endocrinol Metab 38:755–760
Vaitukaitis JL, Ross GT, Braunstein GD, Rayford PL (1976) Gonadotropins and their subunits: Basic and clinical studies. Recent Prog Horm Res 32:289–331
Voss C (1954) Primäres Chorionepitheliom des Magens. Virchows Arch [Pathol Anat] 325:455–464
Yoshimoto Y, Wolfsen AR, Odell WD (1979) Glycosylation: A variable in the production of hCG by cancers. Am J Med 67:414–420
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Mori, H., Soeda, O., Kamano, T. et al. Choriocarcinomatous change with immunocytochemically HCG-positive cells in the gastric carcinoma of the males. Virchows Arch. A Path. Anat. and Histol. 396, 141–153 (1982). https://doi.org/10.1007/BF00431237
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DOI: https://doi.org/10.1007/BF00431237