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Heterogeneous pituitary adenomas

A light microscopic, immunohistochemical and electron microscopic study

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Summary

The combined use of several histological procedures (i.e. conventional light microscopy, immunohistochemistry and electron microscopy) among 45 unselected pituitary adenomas demonstrated the existence of 9 tumors (20%) containing several identifiable adenohypophy seal cell types. Thecellular associations were between 2 or 3 identifiable cell types. Mammosomatotrophic tumors were the most frequent but not the only mixed type (somatomammocorticotrophic, somatocorticotrophic tumors were also found). The cellular components varied in size but the cells appeared randomly distributed in the tumors. In all the adenomas there was an unidentified cell component (no reactivity with antisera used) varying from sparse to numerous elements. On adjacent sections the adenomatous cells reacted with a single specific antiserum, but in two cases the immunohistochemistry on contiguous paraffin embedded sections did not confirm this with certainty. These results confirm those of others and a new term is purposed to designate these tumors: heterogeneous pituitary adenomas. According to the nature and the proportions of the cell components the heterogeneous adenomas were subdivided into two groups: a group A which comprised adenomas formed by a major identifiable cellular type associated with one or two other less frequent cell types, and a group B formed by a predominant unidentifiable (no reactivity with immunochemical stainings) cell type associated with one or two other identified cell types. The present morphofunctional classifications of pituitary adenomas should be modified to include homogeneous adenomas with a single cell type and heterogeneous adenomas with several cell types.

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References

  • Brun JM, Bloch B, Bugnon C, Putelat R (1979) Grossesse gemellaire après bromocriptine chez une acromégale restée stérile après exérèse d'un adénome hypophysaire. Ann Endocrinol 40:551–552

    Google Scholar 

  • Corenblum B, Sirek AMT, Horvath E, Kovacs K, Ezrin C (1976) Human mixed somatotrophic and lactotrophic pituitary adenomas. J Clin Endocrinol Metab 42:857–863

    Google Scholar 

  • Cravioto H, Fukaya T, Zimmerman EA, Kleinberg DL, Flamm ES (1981) Immunohistochemical and electron-microscopic studies of functional and non functional pituitary adenomas including one TSH secreting tumor in a thyrotoxic patient. Acta Neuropathol (Berl) 53:281–292

    Google Scholar 

  • Cunningham GR, Huckins C (1977) An FSH and prolactin secreting pituitary tumor: pituitary dynamics and testicular histology. J Clin Endocrinol Metab 44:248–253

    Google Scholar 

  • Demura R, Kubo O, Demura H, Shizume K (1977) FSH and LH secreting pituitary adenoma. J Clin Endocrinol Metab 45:653–657

    Google Scholar 

  • Duello TM, Halmi NS (1977) Pituitary adenoma producing thyrotropin and prolactin. Virchows Arch [Pathol Anat] 376:255–265

    Google Scholar 

  • Duello TM, Halmi NS (1980) Immunocytochemistry of prolactin-producing human pituitary adenomas. Am J Anat 158:463–469

    Google Scholar 

  • Ezrin C, Horvath E, Kovacs E (1979) Anatomy and cytology of the normal and abnormal pituitary gland. In: De Groot LJ, Cahill JF, Odell W, Martini L, Potts JT, Nelson Don H, Steinberger E, Winegrad AI. (eds): Endocrinology Vol 1. Grune and Stratton, New York pp 103–121

    Google Scholar 

  • Favre L, Rogers LM, Cobb CA, Rabin D (1979) Gigantism associated with a pituitary tumor secreting growth hormone and prolactin and cured by transsphenoidal hypophysectomy. Acta Endocrinol 91:193–200

    Google Scholar 

  • Girod C, Dubois MP, Trouillas J (1976) Apport de l'immunofluorescence à l'étude cytologique des adénomas hypophysaires humains. Ann Endocrinol 37:279–280

    Google Scholar 

  • Girod C, Mazzuca M, Trouillas J, Tramu G, Lhéritier M, Beauvillain JC, Claustrat B, Dubois MP (1980) Light microscopy, fine structure and immunohistochemistry studies of 278 pituitary adenomes. In: Derome PJ, Jedynak CP, Peillon F (eds) II European Workshop on pituitary adenomas, Asclepios Publ Ed, Paris, pp 3–18

    Google Scholar 

  • Guyda H, Robert F, Colle E, Hardy J (1973) Histologic, ultrastructural and hormonal characterization of a pituitary tumor secreting both hGH and prolactin. J Clin Endocrinol Metab 36:531–547

    Google Scholar 

  • Halmi NS, Duello TM (1976) “acidophilic” pituitary tumors. Arch Pathol Lab Med 100:346–351

    Google Scholar 

  • Hardy J, Vezina JL (1976) Transsphenoidal neurosurgery of intracranial neoplasm. Adv Neurol 15:261–274

    Google Scholar 

  • Heitz PU (1979) Multihormonal pituitary adenomas. Horm Res 10:1–13

    Google Scholar 

  • Horn K, Erhardt F, Pickardt CR, Werder K, Scriba PC (1976) Recurent goiter, hyperthyroidism, galactorrhea due to a thyrotropin and prolactin producing pituitary tumor. J Clin Endocrinol Metab 43:137–143

    Google Scholar 

  • Horvath E, Kovacs K (1976) Ultrastructural classification of pituitary adenomas. Can J Neurol Sci 3:9–21

    Google Scholar 

  • Horvath E, Kovacs K, Singer W, Ezrin C, Kerenyi NA (1977) Acidophil stem cell adenoma of the human pituitary. Arch Pathol Lab Med 101:594–599

    Google Scholar 

  • Ilse G, Ryan N, Kovacs K, Ilse D (1980) Calcium deposition in human pituitary adenomas studied by histology, electron microscopy, electron diffraction and X ray spectrometry. Exp Pathol Bd 18, 377–376

    Google Scholar 

  • Kovacs K, Corenblum B, Sirek AM, Penz G, Ezrin C (1976) Localization of prolactin in chromophobe pituitary adenomas: study of human necropsy material by immunoperoxidase technique. J Clin Pathol 29:250–258

    Google Scholar 

  • Kovacs K, Horvath E, Ryan N, Ezrin C (1980) Null cell adenoma of the human pituitary. Virchows Arch [Pathol Anat] 387:165–174

    Google Scholar 

  • Landolt AM (1975) Ultrastructure of the human sella tumors. Acta Neurochir [Suppl] 22:1–167

    Google Scholar 

  • Landolt AM (1978) Praktische Bedeutung neuer Erkenntnisse über Struktur und Funktion von Hypophysenadenomen. Schweiz Med Wochenschr 108:1521–1535

    Google Scholar 

  • Linquette M, Herlant M, Fossati P, May JP, Decoulx M, Fourlinnie JC (1969) Adénome hypophysaire à cellules thyréotropes avec hyperthyroïdie. Ann Endocrinol 30:731–740

    Google Scholar 

  • Martinez AJ, Lee A, Moossy J, Maroon JC (1980) Pituitary adenomas: clinocopathological and immunohistochemical study. Ann Neurol 7:24–36

    Google Scholar 

  • Müller OA, Fink R, Werder KV, Scriba PC (1978) Hypersecretion of ACTH, growth hormone and prolactin in a patient with pituitary adenoma. Acta Endocrinol 87 (suppl 215): 4–5

    Google Scholar 

  • Peillon F, Vila-Porcile E, Olivier L, Racadot J (1970) L'action des oestrogènes sur les adénomes hypophysaires chez l'homme. Ann Endocrinol 31:259–270

    Google Scholar 

  • Pelletier G, Leclerc R, Labrie F (1976) Identification of gonadotropic cells in the human pituitary by immunoperoxydase technique. Mol Cell Endocrinol 6:123–138

    Google Scholar 

  • Pelletier G, Leclerc R, Labrie F, Cote J, Chretien M, Lis M (1977) Immunohistochemical localization of β lipotrophic hormone in the pituitary gland. Endocrinology 100:770–776

    Google Scholar 

  • Phifer R, Midgley AR, Spicer SS (1973) Immunohistologic and histologic evidence that folliclestimulating hormone and luteinizing hormone are present in the same cell type in the human pars distalis. J Clin Endocrinol Metab 36:125–141

    Google Scholar 

  • Roy S (1977) Ultrastructure of chromophobe adenoma of the human pituitary gland. J Pathol 122:219–223

    Google Scholar 

  • Saeger W (1977) Die Hypophysentumoren. In: Büngeler W, Eder M, Lennert K, Peters G, Sandritter W, Seifert G. (eds). Veröffentlichungen aus der Pathologie Vol 107. G Fischer, Stuttgart-New-York pp 1–240

    Google Scholar 

  • Scanarini M, Mingrino S (1979) Pituitary adenomas secreting more than two hormones. Acta Neuropathol 48:67–72

    Google Scholar 

  • Schechter J (1973) Electron microscopic studies of the human pituitary tumors. I-chromophobic adenomas. Am J Anat 158:371–386

    Google Scholar 

  • Shimizu T, Ishida Y, Takeda F (1978) Electron microscopy of the human pituitary adenomas. Correlation of the secretory granules with experimentally and clinically evaluated hormone synthesis function of the adenoma tissue. Neurol Med Chir 18:107–117

    Google Scholar 

  • Solcia E, Capella C, Buffa R, Frigerio B, Fontana P, Usellini L (1977) Tumori dell' adenoipofisi: diagnosi morfologica e classificazione. Pathologica 69:333–346

    Google Scholar 

  • Trouillas J, Girod C, Lhéritier M, Claustrat B, Dubois MP (1980) Morphological and biochemical relationships in 31 human pituitary adenomas with acromegaly. Virchows Arch [Pathol Anat] 389:127–142

    Google Scholar 

  • Ueda G, Moy P, Furth J (1973) Multihormonal activities of normal and neoplastic pituitary cells as indicated by immunohistochemical staining. Int J Cancer 12:100–114

    Google Scholar 

  • Zimmerman EA, Defendini R, Frantz AG (1974) Prolactin and growth hormone in patients with pituitary adenomas: a correlative study of hormone in tumor and plasma by immunoperoxydase technique and radioimmunoassay. J Clin Endocrinol Metab 38:577–585

    Google Scholar 

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Authors and Affiliations

  1. Laboratoire d'Histologie, Faculté de Médecine, 2 rue du Docteur Marcland, F-87032, Limoges, Cedex, France

    D. Martinez & D. Barthe

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  1. D. Martinez
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  2. D. Barthe
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Martinez, D., Barthe, D. Heterogeneous pituitary adenomas. Virchows Arch. A Path. Anat. and Histol. 394, 221–233 (1982). https://doi.org/10.1007/BF00430667

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