Summary
In 9 of 12 patients suffering from lens-induced uveitis lymphocyte transformation could be induced in vitro with alphacrystalline, an isolated organ-specific antigen of the lens. This antigen also inhibited leukocyte migration in 8 out of 11 patients. The available date strongly suggest the cellular hypersensitivity to alpha-crystalline to be primarily involved in the development of this form of uveitis.
Zusammenfassung
Bei 9 von 12 Patienten mit linsenbedingter Uveitis konnte in vitro eine Lymphocytentransformation mit Alpha-Kristallin beobachtet werden. Es handelt sich hierbei um ein isoliertes, organspezifisches Linsenantigen. Dieses führte bei 8 von 11 Patienten auch zu einer Hemmung der Leukocytenmigration. Die festgestellten Ergebnisse lassen den Schluß zu, daß die celluläre Überempfindlichkeit auf Alpha-Kristallin primär bei der Entwicklung dieser Uveitis-Form beeinträchtigt ist.
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Hammer, H., Olah, M. Cellular hypersensitivity to lenticular protein in lens-induced uveitis. Albrecht von Graefes Arch. Klin. Ophthalmol. 192, 339–344 (1974). https://doi.org/10.1007/BF00429994
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DOI: https://doi.org/10.1007/BF00429994