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Modification of the behavioral response to drugs in rats exposed prenatally to chlorpromazine

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Abstract

Female rats exposed prenatally to low levels of chlorpromazine were less susceptible as adults to the rate-reducing effects of chlorpromazine and pentobarbital on fixed-interval performance of a food-reinforced operant. Males were not significantly affected by prenatal treatment.

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Supported by NIMH grant MH 12568 and Research Scientist Award (Conan Kornetsky) MH 01759. We thank John Rizzo for carrying out the behavioral testing.

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Golub, M., Kornetsky, C. Modification of the behavioral response to drugs in rats exposed prenatally to chlorpromazine. Psychopharmacologia 43, 289–291 (1975). https://doi.org/10.1007/BF00429267

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  • DOI: https://doi.org/10.1007/BF00429267

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