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Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline

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Abstract

Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been shown to cause a decrease in the number of muscarinic receptors. Thus, the long-term use of cholinergic precursors could have some adverse effects on central cholinergic functioning.

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References

  • Bartus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408–417

    Google Scholar 

  • Ben-Barak J, Gazit H, Silman I, Dudai Y (1981) In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands. Eur J Pharmacol 74:73–81

    Google Scholar 

  • Friedman MJ, Jaffe JH (1969) A central hypothermic response to pilocarpine in the mouse. J Pharmacol Exp Ther 167:34–44

    Google Scholar 

  • Krnjević K, Reinhardt W, Ropert N (1982) Choline as an acetylcholine agonist in the mammalian neocortex and hippocampus. In: Corkin S, Davis KL, Growdon JH, Usdin E (eds) Alzheimer's disease: A report of progress in research (Aging, vol 19). Raven, New York

    Google Scholar 

  • Lomax P, Jenden DJ (1966) Hypothermia following systemic and intracerebral injection of oxotremorine in the rat. Int J Neuropharmacol 5:353–359

    Google Scholar 

  • Palacios JM, Kuhar MJ (1979) Choline: Binding studies provide some evidence for a weak, direct agonist action in brain. Mol Pharmacol 16:1084–1088

    Google Scholar 

  • Speth RC, Yamamura HI (1979) On the ability of choline and its analogues to interact with muscarinic cholinergic receptors in the rat brain. Eur J Pharmacol 58:197–201

    Google Scholar 

  • Ulus IH, Wurtman RJ (1976) Choline administration: Activation of tyrosine hydroxylase in dopaminergic neurons of rat brain. Science 194:1060–1061

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, Wayne State University School of Medicine, 48202, Detroit, MI, USA

    Nunzio Pomara, Robert Block, Michael Stanley & Samuel Gershon

  2. Department of Pharmacology, Wayne State University School of Medicine, 48202, Detroit, MI, USA

    Michael Stanley

  3. Division of Pharmacology, Lafayette Clinic, 951 E. Lafayette, 48207, Detroit, MI, USA

    Sandra Demetriou, Franz Fucek & Michael Stanley

  4. Geriatric Study-Treatment Program, Lafayette Clinic, 951 E. Lafayette, 48207, Detroit, MI, USA

    Nunzio Pomara & Robert Block

Authors
  1. Nunzio Pomara
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  2. Robert Block
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  3. Sandra Demetriou
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  4. Franz Fucek
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  5. Michael Stanley
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  6. Samuel Gershon
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Pomara, N., Block, R., Demetriou, S. et al. Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline. Psychopharmacology 80, 129–130 (1983). https://doi.org/10.1007/BF00427955

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  • DOI: https://doi.org/10.1007/BF00427955

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