Abstract
Male albino guinea pigs aged 4–10 weeks were challenged with 0.1, 0.2, and 0.4 mg/kg apomorphine. Mean stereotypy scores rose significantly as a function of age. Stereotypy scores were better correlated with age than with body weight, suggesting that CNS maturation, rather than weight-related factors, was responsible. Although age and body weight were correlated, there was enough variability to make body weight an unreliable indicator of age.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Carlson, K. R., Almasi, J.: Behavioral supersensitivity to apomorphine following chronic narcotic treatment in the guinea pig. Psychopharmacology 57, 273–277 (1978)
Coyle, J., Axelrod, J.: Tyrosine hydroxylase in rat brain: developmental characteristics. J. Neurochem. 19, 1117–1123 (1972)
Eibergen, R. D., Carlson, K. R.: Behavioral evidence for dopaminergic supersensitivity following chronic treatment with methadone or chlorpromazine in the guinea pig. Psychopharmacology 48, 139–146 (1976)
Fog, R.: On stereotypy and catalepsy: studies on the effect of amphetamines and neuroleptics in rats. Acta Neurol. Scand. [Suppl. 50] 48, 11–64 (1972)
Fuxe, K., Ungerstedt, U.: Histochemical, biochemical and functional studies on central monoamine neurons after acute and chronic amphetamine administration. In: Amphetamines and related compounds, E. Costa and S. Garattini, eds., pp. 257–288. New York: Raven Press 1970
Hudick, J. P., Wajda, I. J., Lajtha, A.: The amphetamine-induced inhibition of dopamine biosynthesis in rat striatum. Eur. J. Pharmacol. 35, 389–392 (1976)
Keller, H. H., Bartholini, G., Pletscher, A.: Spontaneous and drug-induced changes of cerebral dopamine turnover during postnatal development of rats. Brain Res. 64, 371–378 (1973)
Kellogg, C., Lundborg, P.: Ontogenic variation in response to l-DOPA and monoamine receptor-stimulating agents. Psychopharmacologia (Berl.) 23, 187–200 (1972)
Kellogg, C., Wennerstrom, G.: An ontogenic study on the effect of catecholamine receptor-stimulating agents on the turnover of noradrenaline and dopamine in the brain. Brain Res. 79, 451–464 (1974)
Kilbey, M. M., Ellinwood, E. H., Jr.: The effect of age-related factors on behavior induced by cocaine. Life Sci. 20, 1847–1854 (1977)
Klawans, H. L., Margolin, D. I.: Amphetamine-induced dopaminergic hypersensitivity in guinea pigs: Implications in psychosis and human movement disorders. Arch. Gen. Psychiatry 32, 725–732 (1975)
Klawans, H. L., Crossett, P., Dana, N.: Effect of chronic amphetamine exposure on stereotyped behavior: implications for pathogenesis of l-DOPA-induced dyskinesias. In: Advanes in neurology, vol. 9, D. B. Calne, T. N. Chase, and A. Barbeau, eds., pp. 105–112. New York: Raven Press 1975
Lal, S., Feldmuller, F.: Effect of amphetamine and apomorphine on brain monoamines and behavior in the immature and young adult rat. Arch. Int. Pharmacodyn. 218, 239–251 (1975)
Lal, S., Sourkes, T. L.: Ontogeny of stereotyped behavior induced by apomorphine and amphetamine in the rat. Arch. Int. Pharmacodyn. 202, 171–182 (1973)
Lanier, L. P., Dunn, A. J., Van Hartesveldt, C.: Development of neurotransmitters and their function in brain. In: Reviews of neuroscience, vol. 2 S. Ehrenpreis and I. J. Kopin, eds., pp. 195–256. New York: Raven Press 1976
McGeer, E. G., Fibiger, H. C., Wickson, V.: Differential development of caudate enzymes in the neonatal rat. Brain Res. 32, 433–440 (1971)
Randrup, A., Munkvad, I.: Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia (Berl.) 11, 300–310 (1967)
Segal, D. S., Mandell, A. J.: Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotypy. Pharmacol. Biochem. Behav. 2, 249–255 (1974)
Winer, B. J.: Statistical principles in experimental design, 2nd ed. New York: McGraw-Hill 1971
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carlson, K.R., Almasi, J. Sensitivity to apomorphine in the guinea pig as a function of age and body weight. Psychopharmacology 57, 279–282 (1978). https://doi.org/10.1007/BF00426751
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00426751