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HLA-B27 frequency and MLC reactions in acute anterior uveitis

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Abstract

HLA-A and B antigens were determined in 37 unrelated patients with acute non-granulomatous anterior uveitis (AAU) and in 114 control subjects. HLA-B27 was identified in 31 patients with AAU (83.8%) and in 15 control subjects (13.2%). Fifteen patients (40.5%) had associated rheumatic diseases and all of them (100%) had HLA-B27. Of the 22 patients without any associated disease, 16 (72.7%) had HLA-B27. To study the HLA-D composition MLC tests were done as one-way microcultures between members of four groups consisting of 10, 10, 8, and 8 patients with AAU and two or three healthy controls in each test group. No difference between patient-to-patient reactions as compared with the control reactions could be observed. The results show that AAU is very closely associated with HLA-B27 but not with any of the HLA-D antigens.

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Authors and Affiliations

  1. Institute of Clinical Sciences, University of Tampere, Tampere, Finland

    K. M. Saari, J. Häkli, J. Solja, A. Kaakinen, S. Seppänen, S. Kallio & M. Kataja

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  1. K. M. Saari
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  2. J. Häkli
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  3. J. Solja
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  4. A. Kaakinen
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  5. S. Seppänen
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  6. S. Kallio
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  7. M. Kataja
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Additional information

Supported by grants from The Finnish Rheumatism Association, The Medical Research Council of the Academy of Finland, and The Sigrid Jusélius Foundation, Finland

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Saari, K.M., Häkli, J., Solja, J. et al. HLA-B27 frequency and MLC reactions in acute anterior uveitis. Albrecht von Graefes Arch. Klin. Ophthalmol. 216, 23–29 (1981). https://doi.org/10.1007/BF00407773

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  • DOI: https://doi.org/10.1007/BF00407773

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