Abstract
Antibodies to sulfolipids were demonstrated in patients suffering from lepromatous leprosy. The antibody titre was found to decrease gradually on treatment with DDS. This effect was maximum for patients undergoing treatment for more than 1 year.
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Bjune G., Barnetson R. St C., Ridley D. S. and Kronvall G. 1976. Lymphocyte transformation test in leprosy; correlation of the response with inflammation of lesions. — Clin. Exp. Immunol. 25: 85–94.
Gidoh M., Tsutsumi S., Narita M. and Fukushi K. 1979. Influences of several antileprosy drugs on immunological state of experimental animals. — Jpn. J. Lepr. 48: 159–170.
Harboe M. and Closs O. 1980. Immunological aspects of leprosy. p. 1231–1243. In M.Fougereau and J.Dausset (eds), Progress in Immunology, Vol. 4. — Academic Press, London.
Khuller G. K., Malik U. and Kumar B. 1982a. Antibodies to sulfolipids in human leprosy sera. — Int. J. Lepr. 50: 319–321.
Khuller G. K., Malik U. and Nalini P. 1982b. Antibodies to mycobacterial sulfolipids in human tuberculous sera. — IRCS Med. Sci. 9: 492.
Malik U. and Khuller G. K. 1982. Antibody response to sulfolipids in experimental tuberculosis. — Antonie van Leeuwenhoek 48: 285–288.
Melsom R., Naafs B., Harboe M. and Closs O. 1978. Antibody activity against Mycobacterium leprae antigen-7 during the first year of DDS treatment in lepromatous (BL-LL) leprosy. — Lepr. Rev. 49: 17–29.
Myrvang B., Godal T., Ridley D. S., Froland S. S. and Song Y. K. 1973. Immune responsive to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. Clin. Exp. Immunol. 14: 541–543.
Navalkar R. G., Norlin M. and Ouchterlony O. 1964. Characterization of leprosy sera with various mycobacterial antigens using double diffusion in gel analysis. A preliminary report. —Int. Arch. Allergy Appl. Immunol. 25: 105–113.
Pinto M. R. M. and Asseculeratne S. N. 1974. An investigation of Takahashi's antitubercle phosphatide kaolin agglutination test (KAT) in leprosy. — Int. J. Lepr. 42: 48–51.
Prabhudesai A. V., Malik U., Subrahmanyam D. and Khuller G. K. 1981. Isolation and purification of sulfolipids of Mycobacterium tuberculosis H37Rv. — Indian J. Biochem. Biophys. 18: 71–73.
Rees R. J. W., Chatterjee K. R., Pepys J. and Tee R. D. 1965. Some immunologic aspects of leprosy. — Am. Rev. Respir. Dis. 92 (Suppl.): 139–149.
Takahashi Y. 1962. Serum agglutination of kaolin particles sensitized with tubercle phosphatide and its clinical evaluation as a sero-diagnostic test for tuberculosis. — Am. Rev. Respir. Dis. 85: 708–719.
Trana A. K., Sehgal S. C. and Khuller G. K. 1978. Antibodies to phospholipids in experimental nocardiosis. — Antonie van Leeuwenhoek 44: 391–394.
Yoder L., Naafs B., Harboe M. and Bjune G. 1979. Antibody activity against Mycobacterium leprae antigen 7 in leprosy. Studies on variation in antibody content throughout the spectrum and on the effect of DDS treatment and relapse in BT leprosy. — Lepr. Rev. 50: 113–121.
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Malik, U., Khuller, G.K. & Kumar, B. Suppression of the antibody response to sulfolipids in leprosy patients by 4,4′-diaminodiphenyl sulfone (DDS). Antonie van Leeuwenhoek 49, 579–583 (1983). https://doi.org/10.1007/BF00399851
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DOI: https://doi.org/10.1007/BF00399851