Abstract
A new thymocyte membrane-brain antigenic system is defined for the mouse and rat. Monoclonal antibody NIM-M129 recognizes a membrane antigen that has a similar size to Thy-1 (20–23 kd) but entirely different tissue distribution. It is absent from cortisone-resistant thymocytes, murine peripheral T cells, T-cell blasts, and T-cell lymphomas, or rat bone marrow. However, the determinant exhibits a quantitative difference in expression on thymocytes of Thy-1 a (low) and Thy-1 b (high) mice, with intermediate values for their F1 progeny. Backcross and F2 segregation tests between CBA and CBA-Thy-1a congenic lines established firm genetic linkage between Thy-1 and the level of epitope expression on the thymocyte cell surface.
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Oliveira, O.L.P., Thomas, D.B. A new thymocyte membrane differentiation antigen for mouse and rat. Immunogenetics 21, 559–568 (1985). https://doi.org/10.1007/BF00395880
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DOI: https://doi.org/10.1007/BF00395880