Summary
Investigations were carried out in an alkaline battery factory. The study group consisted of 102 persons and the control group of 85 persons. Cadmium in blood (Cd-B) and cadmium in urine (Cd-U), as well as β2-microglobulin (B2-M), retinol binding protein (RBP), amino acids in urine were determined. Exposure to cadmium was high; Cd-B and Cd-U concentrations were higher than recommended, 10 gmg/l and 10 gmg/g creat. in 65% and 56% of workers, respectively. Excretion of B2-M and RBP in urine was higher than the accepted upper limits of 380 and 130 I μg/g creat. in about 20% of the workers. A significant correlation was observed between: log Cd-U log Cd-B (r = 0.85), log B2-M log RBP (r = 0.66), log Cd-U · log B2- M (r = 0.52), and log Cd-U · log RBP (r = 0.55). To evaluate the admissible period of occupational exposure to cadmium, an integrated exposure index (Cd-B × years of exposure) is proposed. According to the dose-response relationship, an increase of low molecular protein excretion in urine can be expected in 10% of the cases at Cd-U amounting to 10 to 15 μg/g creat. and Cd-B × years of about 300 to 400.
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References
Bernard A, Buchet JP, Roels H, Masson P, Lauwerys R (1979) Renal excretion of proteins and enzymes in workers exposed to cadmium. Eur J Clin Invest 9:11–22
Bernard AM, Moreau D, Lauwerys RM (1982) Latex immunoassay of retinol — binding protein. Clin Chem 28:1167–1171
Da Silva PE, Donnan NB (1981) Chronic cadmium poisoning in a pigment manufacturing plant. Br J Ind Med 38:76–86
Elinder CG, Edling C, Lindberg E, Kagedal B, Vesterberg O (1985) Assessment of renal function in workers previously exposed to cadmium. Br J Ind Med 42:754–760
Ellis KJ, Cohn SH, Smith TJ (1985) Cadmium inhalation exposure estimates: their significance with respect to kidney and liver cadmium burden. J Toxicol Environ Health 15:173–187
Ewers U, Brockhaus A, Dolgner R, Freir L, Jerman E, Bernard A, Stiller-Winkler R, Hahn R, Manojlovic N (1985) Environmental exposure to cadmium and renal function of elderly women living in cadmium-polluted areas of the Federal Republic of Germany. Int Arch Occup Environ Health 55:217–239
Falck FY, Fine LJ, Smith RG, McClatchey KD, Annesley T, England B, Scherk AM (1983) Occupational cadmium exposure and renal status. Am J Ind Med 4:541–549
Ghezzi I, Toffoletto F, Sesana G, Fagiolo MG, Micheli A, Di Silvestro P, Zocchetti C, Alessio L (1985) Behaviour of biological indicators of cadmium in relation to occupational exposure. Int Arch Occup Environ Health 55:133–140
Hassler E, Lind B, Piscator M (1983) Cadmium in blood and urine related to present and past exposure. A study of workers in an alkaline battery factory. Br J Ind Med 40:420–425
Kowal NE, Zirkes M (1963) Urinary cadmium and beta2-microglobulin: normal values and concentration adjustment. J Toxicol Environ Health 11:607–624
Lauwerys R, Roels H, Regniers M, Buchet JP, Bernard A, Goret A (1979) Significance of cadmium concentration in blood and in urine of workers exposed to cadmium. Environ Res 20:375–391
Lind B (1983) Deproteinization method for electrothermal atomization, analysis of lead and cadmium in blood by AAS. In: Epidemiological study protocol on biological indicators of lead neurotoxicity in children. WHO Nr ICR/RCE 903
Nomiyama K, Nomiyama H (1984) Reversibility of cadmium-induced effects in rabbits. Environ Health Persp 54:201–211
Piscator M (1982) Cadmium — exposure and effects in the general population and occupationally exposed workers. In: Clinical, biochemical and nutritional aspects of trace elements. A R Liss Inc, New York, pp 521–536
Roels HA, Lauwerys RT, Buchet JP, Bernard A (1981) Environmental exposure to cadmium and renal function of aged women in three areas of Belgium. Environ Res 24:117–130
Roels H, Lauwerys R, Buchet JP, Bernard A, Garvey JS, Linton HJ (1983) Significance of urinary metallothionein in workers exposed to cadmium. Int Arch Occup Environ Health 52:159–166
Rogaczewska T, Matczak W (1985) Evaluation of occupational exposure to cadmium based on air analysis at workplace. I. Cadmium oxide in air at the nickel-cadmium battery plant. Med Pracy 35:273–279 (in Polish)
Shigematsu I, Minowa M, Yoshida T, Miyamoto K (1979) Recent results of health examinations of the general population in cadmium-polluted and control areas in Japan. Environ Health Persp 28:205–210
Stoeppler M, Brandt K (1980) Contributions to automated trace analysis. Part V: Determination of cadmium in whole blood and urine by electrothermal atomic-absorption spectrophotometry. Fresenius Z Anal Chem 300:372–380
Suzuki KT (1984) Studies of cadmium uptake and metabolism by the kidney. Environ Health Persp 54:21–30
WHO (1980) Recommended health-based limits in occupational exposure to heavy metals. Tech Rep Ser 647, WHO, Geneva
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Jakubowski, M., Trojanowska, B., Kowalska, G. et al. Occupational exposure to cadmium and kidney dysfunction. Int. Arch Occup Environ Heath 59, 567–577 (1987). https://doi.org/10.1007/BF00377920
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DOI: https://doi.org/10.1007/BF00377920