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Intracellular calcium does not directly modulate cardiac pacemaker (if) channels

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  • Excitable Tissues and Central Nervous Physiology
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Abstract

A study on the cardiac pacemaker current if in inside-out macro-patches of sino-atrial (SA) node cells has recently demonstrated that if channels are directly activated by intracellular cAMP [4]. Using the same preparation, here we investigate the possibility that internal Ca2+ ions play a role in the modulation of if channels. Our results indicate that Ca2+ ions do not have a direct activating effect on if.

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Authors and Affiliations

  1. Dipartimento di Fisiologia e Biochimica Generali, Elettrofisiologia, Università di Milano, via Celoria 26, I-20133, Milano, Italy

    A. Zaza, G. Maccaferri, M. Mangoni & D. DiFrancesco

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  1. A. Zaza
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  2. G. Maccaferri
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  3. M. Mangoni
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  4. D. DiFrancesco
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Zaza, A., Maccaferri, G., Mangoni, M. et al. Intracellular calcium does not directly modulate cardiac pacemaker (if) channels. Pflügers Arch 419, 662–664 (1991). https://doi.org/10.1007/BF00370312

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  • DOI: https://doi.org/10.1007/BF00370312

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