Summary
When fresh platelets were incubated in serum to which heat-aggregated IgG was added, the increase of platelet-associated IgG was paralleled by increased levels of platelet-associated IgM, IgA and albumin as determined by ELISA. The increase was observed regardless of whether the platelets were quantified by conventional platelet counting or with the help of 51Cr-labelling, which was done to avoid potential counting errors induced by platelet fragmentation. In thrombocytopenic patients a correlation between in vivo bound platelet-associated albumin and IgG could be confirmed. It was concluded that aggregated IgG induces an increased binding of serum immunoglobulins and albumin to platelets in vitro.
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Winiarski, J. Immunoglobulin binding to platelets. The effect of aggregated IgG. Blut 51, 259–266 (1985). https://doi.org/10.1007/BF00320520
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DOI: https://doi.org/10.1007/BF00320520