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Plasma exchange: a treatment for neuropathy associated with IgG-kappa gammopathy

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Summary

A patient with a peripheral neuropathy associated with an IgG-kappa gammopathy is reported who was treated with plasma exchange as the only therapeutic modality and showed dramatic clinical improvement, which fluctuated based on the frequency of plasma exchange. Therapeutic plasma exchange is recommended as one form of possible treatment for neuropathies resulting from IgG gammopathies. The literature is reviewed.

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References

  1. Bosch EP, Ansbacher LE, Goeken JA, Cancilla PA (1982) Peripheral neuropathy associated with monoclonal gammopathy. Studies of intraneural injections of monoclonal immunoglobulin sera. J Neuropathol Exp Neurol 41:446–459

    Google Scholar 

  2. Dalakas MC, King Engel W (1981) Polyneuropathy with monoclonal gammopathy: studies of 11 patients. Ann Neurol 10:45–52

    Google Scholar 

  3. Ernerudh J, Brodtkorb E, Olsson T, Vedeler CA, Nyland H, Berlin G (1986) Peripheral neuropathy and monoclonal IgM with antibody activity against peripheral nerve myelin; effect of plasma exchange. J Neuroimmunol 11:171–178

    Google Scholar 

  4. Haas DC, Tatum AH (1988) Plasmapheresis alleviates neuropathy accompanying IgM anti-myelin-associated glycoprotein paraproteinemia. Ann Neurol 223:394–396

    Google Scholar 

  5. Hafler DA, Johnson D, Kelly JJ, Panitch H, Kyle R, Weiner HL (1986) Monoclonal gammopathy and neuropathy: myelin-associated glycoprotein reactivity and clinical characteristics. Neurology 36:75–78

    Google Scholar 

  6. Kelly JJ, Kyle RA, O'Brien PC, Dyck PJ (1981) Prevalence of monoclonal protein in peripheral neuropathy. Neurology 31:1480–1483

    Google Scholar 

  7. Medical Research Council (1976) Aids ot the examination of the peripheral nervous system. Her Majesty's Stationery Office, London, Memorandum no. 45

    Google Scholar 

  8. Nobile-Orazio E, Baldini L, Barbieri S (1988) Treatment of patients with neuropathy and anti-MAG IgM M-protein. Ann Neurol 24:93–97

    Google Scholar 

  9. Sherman WH, Olarte MR, McKiernan G, Sweeney K, Latov N, Hays AP (1984) Plasma exchange treatment of peripheral neuropathy associated with plasma cell dyscrasia. J Neurol Neurosurg Psychiatry 47:813–819

    Google Scholar 

  10. Smith T, Sherman W, Olarte MR, Lovelace RE (1987) Peripheral neuropathy associated with plasma cell dyscrasia: a clinical and electrophysiological follow-up study. Acta Neurol Scand 75:244–248

    Google Scholar 

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Fineman, S.M., McKendall, R.R. Plasma exchange: a treatment for neuropathy associated with IgG-kappa gammopathy. J Neurol 237, 85–87 (1990). https://doi.org/10.1007/BF00314667

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  • DOI: https://doi.org/10.1007/BF00314667

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