Summary
Using the method of haemagglutination inhibition, the authors determined the levels of measles antibodies in the saliva of 14 children with subacute sclerosing panencephalitis. In 13 of them these antibodies were found in titres from 1:8 to 1:128. In the control groups, comprising 29 children, these antibodies were found in the saliva in only two cases and in low titres. There appears to be a correlation between the levels of these antibodies in the saliva and cerebrospinal fluid in patients with subacute sclerosing panencephalitis.
Zusammenfassung
Es wurden Untersuchungen über den Masernantikörpertiter im Speichel von 14 SSPE-kranken Kindern durchgeführt. In 13 dieser Fälle wurden Titer von 1:8 bis 1:128 gefunden. In zwei insgesamt 29 Kinder umfassenden Kontrollgruppen wurden im Speichel Masernantikörper nur zweimal in den niedrigsten Titern festgestellt. Es scheint, daß bei den Patienten mit der SSPE eine Korrelation zwischen den Masernantikörpertitern im Blut und jenen im Speichel besteht.
References
Bellanti JA, Sanga RL, Klutinis B, Artenstein MS (1969) Antibody responses in serum and nasal secretions of children immunized with inactivated and attenuated measles virus vaccines. N Engl J Med 280:628–633
Craddock-Watson JE, Ridehalgh MKS (1973) Nasal immunoglobulin response in acute rubella determined by the immunofluorescent technique. J Hyg (Lond) 71:603–631
Derakhshan I, Mirchamsy H, Shafii A (1979) Subacute sclerosing panencephalitis. Immunological findings in saliva and salivary glands. Eur Neurol 18:79–83
Downie JC (1973) The sequential appearance of antibody and immunoglobulin in nasal secretion after immunization of volunteers with live inactivated influenza B virus vaccines. J Hyg (Lond) 71:433–445
Polna I, Cendrowski W (1977) Serological studies on the etiological role of measles-like virus in subacute sclerosing panencephalitis. J Neurol 216:301–310
Polna I, Aleksandrowicz J, Krawczyński K, Krotochwil-Skrzypek M, Roszkowska K (1977) Measles antibodies in nasal secretions and sera of children with measles. Acta Virol (Praha) 21:331–337
Wrzos H, Kulczycki J, Laskowski Z, Matacz D, Brzosko W (1979) Detection of measles virus antigen(s) in peripheral lymphocytes from patients with subacute sclerosing panencephalitis. Arch Virol 60:291–297
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Sobczyk, W., Polna, I., Kulczycki, J. et al. Measles antibodies in the saliva of children with subacute sclerosing panencephalitis. J Neurol 228, 219–222 (1982). https://doi.org/10.1007/BF00313736
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DOI: https://doi.org/10.1007/BF00313736