Abstract
Gastric inhibitory polypeptide (GIP) secretion after distal gastrectomy was compared between patients with diabetes mellitus (DM-group) and patients with normal glucose tolerance (N-group). GIP secretion in the DM-group was significantly greater in the early postcibal response period, but less in the late postcibal response period after gastrectomy, the total secretion of GIP being less after gastrectomy than before in this group. In the N-group, both the early and total postcibal responses of GIP were greater after gastrectomy than before. Moreover, the early and total postcibal secretions of GIP after gastrectomy were less in the DM-group than in the N-group. These findings suggest that GIP secretion in diabetics becomes insufficient after gastrectomy.
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References
Wells C, Welbourn R (1951) Postgastrectomy syndromes. Br Med J 1:546–553
Roth DA, Meade RC (1964) Hyperinsulinism hypoglycemia in the post-gastrectomy patient. Diabetes 14:526–528
Dupre J, Ross SA, Watson D, Brown JC (1973) Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J Clin Endocrinol Metab 37:826–828
Schaffmayer A, Borger HW, Coelle EF, Becker HD (1979) Glucose Homeostase bei resezierenden und nicht resezierenden Verfahren am Magen. Langenbecks Archiv fur Chirurgie [Suppl]: 115–118
Becker HD (1980) Hormonal changes after gastric surgery. In: Creutzfeldt W (ed) Clinics in gastroenterology, vol 9. WB Saunders, London, pp 755–771
Jorde R, Schulz TB, Burhol PG, Schultz LB (1981) The response of plasma gastric inhibitory polypeptide (GIP) to slow and fast glucose ingestion in Billroth II resected patients and normal controls. Regul Pept 2:391–399
Miyata M, Nakao K, Tanaka Y, Sakamoto T, Hamaji M, Taketani H, Kawashima Y (1984) Gastric inhibitory polypeptide secretion after radical pancreatoduodenectomy. Ann Surg 199:281–285
Kuzuya N, Abe M, Ueda H, Kuzuya K, Kuzuya T, Kosaka K, Goto Y, Shigeta Y, Baba S, Hirata Y, Horiuchi H, Yamada K, Wada M (1970) Report of the committee on the diagnostic criteria of the oral glucose tolerance test for diabetes mellitus. Recommendations on the evaluation of the oral glucose tolerance test for the diagnosis of diabetes mellitus (in Japanese). J Jpn Diab Soc 13:1–8
Hermanek P, Sobin LH (1987) TNM classification of malignant tumors, 4th fully revised edn, Springer, Berlin Heidelberg New York, pp 43–46
Sayer A, Gerstenfeld S (1958) The photometric microdetermination of blood glucose with glucose oxidase. J Lab Clin Med 51:448–460
Morgan CR, Lazarow A (1963) Immunoassay of insulin: Two antibody system. Diabetes 12:115–126
Kuzio M, Dryburgh JR, Malloy KM, Brown JC (1974) Radioimmunoassay for gastric inhibitory polypeptide. Gastroenterology 66:357–364
Tanaka Y, Miyata M, Hamaji M, Izukura M, Nakamura M, Kawashima Y (1989) Role of gastric inhibitory polypeptide in altered glucose metabolism after removal of the jejunum in dogs. Surgery 105:502–509
Crockett SE, Mazzaferri EL, Cataland S (1976) Gastric inhibitory polypeptide in maturity-onset diabetes mellitus. Diabetes 25:931–935
Ross SA, Brown JC, Dupre J (1977) Hypersecretion of gastric inhibitory polypeptide following oral glucose in diabetes mellitus. Diabetes 26:525–529
Takemura J, Seino Y, Tsuda K, Seino, S, Ikeda M, Sakurai H, Imura H (1981) Hypersecretion of gastric inhibitory polypeptide induced by glucose ingestion in diabetes mellitus. Endocrinol Japan 28:17–21
May JM, Williams RH (1978) The effect of endogenous gastric inhibitory polypeptide on glucose-induced insulin secretion in mild diabetes. Diabetes 27:849–855
Ebert R, Creutzfeldt W (1980) Hypo- and hypersecretion of GIP in maturity-onset diabetes. Diabetologia 9:271
Creutzfeldt W (1977) Release of gastric inhibitory polypeptide (GIP) to a test meal under normal and pathological conditions in man. In: Bajaj JS (ed) Diabetes. Excerpta Medica, Amsterdam, pp 63–75
Brown JC, Dryburgh JR, Ross SA, Dupre J (1975) Identification and actions of gastric inhibitory polypeptide. Rec Prog Horm Res 31:487–532
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Dousei, T., Miyata, M., Tanaka, Y. et al. Gastric inhibitory polypeptide secretion after gastrectomy in patients with diabetes mellitus. Surg Today 23, 954–959 (1993). https://doi.org/10.1007/BF00308969
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DOI: https://doi.org/10.1007/BF00308969