Summary
It is proposed that the same diseases as those induced by the graftversus-host reaction (GVHR) will arise in nonchimeric individuals, if structures of the major histocompatibility complex (MHC) on lymphocytes are altered, either by viral infection or by chemicals, in such a way that autologous T lymphocytes react against them as the react in the GVHR to semiallogeneic (F1) lymphocytes differing at the MHC. Diseases in which a GVHR-like pathogenesis is suspected will be discussed.
Zusammenfassung
Es wird die Hypothese aufgestellt, daß dieselben Krankeheiten wie bei der Graft-versus-Host-Reaktion (GVHR) aufgrund derselben Pathogenese entstehen können, ohne daß Chimärismus vorliegt. Ätiologische Voraussetzung hierfür ist, daß Strukturen des Haupthistokompatibilitätse-Komplexes (MHC) auf Lymphocyten durch Viren oder Chemikalien in einer Weise verändert werden, die autologe T Lymphocyten veranlaßt dagegen zu reagieren, als handelte es sich um MHC unverträgliche semiallogene (F1) Lymphocyten wie bei der GVHR. Krankheiten, bei denen wir eine GVHR-artige Pathogenese vermuten, werden diskutiert.
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Gleichmann, E., Gleichmann, H. Graft-versus-host reaction: a pathogenetic principle for the development of drug allergy, autoimmunity, and malignant lymphoma in non-chimeric individuals. Hypothesis. Z. Krebsforsch. 85, 91–109 (1976). https://doi.org/10.1007/BF00304942
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DOI: https://doi.org/10.1007/BF00304942