Skip to main content
SpringerLink
Log in

Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside

  • Original Articles
  • Published:
Urological Research Aims and scope Submit manuscript

Summary

The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E1, and phentolamine was studied in 22 adult cats. The maximal erectile response (intracavernous pressure, penile length, and rigidity) was produced by intracavernous injection of a combination of 1.65 mg papaverine, 0.5μg PGE1, and 25μg phentolamine. This combination was considered as “control” in order to compare the effect of other agents. VIP and SNP increased the intracavernous pressure and caused erection in a dose-dependent manner with a maximal response obtained with 5μg VIP or 10μg SNP. The duration of peak erection and the total duration of drug effect were significantly shorter with VIP and SNP than with the reference combination (P<0.01). Epinephrine (30μg) reversed the effects of SNP and significantly shortened the duration of peak action and total effect (P<0.05). This study supports the use of an in vivo feline model for the evaluation of vasoactive agents and demonstrates that the intracavernous injection of either VIP or SNP can induce penile erection in the adult cat.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aboseif SR, Breza J, Bosch RJLH et al. (1989) Local and systemic effects of chronic intracavernous injection of papaverine, prostaglandin E1, and saline in primates. J Urol 142:403

    Google Scholar 

  2. Abozeid M, Juenemann KP, Luo JA, Lue TF, Yen TSB, Tanagho EA (1987) Chronic papaverine treatment: the effect of repeated injections on the simian erectile response and penile tissue. J Urol 138:1263

    Google Scholar 

  3. Brindley GS (1983) Cavernosal alpha-blockage: a new technique for investigating and treating erectile impotence. Br J Psychiatry 143:332

    Google Scholar 

  4. Buvat J, Buvat-Herbaut M, Lemaire A, Marcolin G (1991) Reduced rate of fibrotic nodules in the cavernous bodies following auto-intracavernous injections of moxisylyte compared to papaverine. Int J Impotence Res 3:123

    Google Scholar 

  5. Crouch JE, Lackey MG (1969) Text-atlas of cat anatomy. Lea and Febiger, Philadelphia, p 160

    Google Scholar 

  6. Domer FR, Wessler G, Brown RL, Charles HC (1978) Involvement of the sympathetic nervous system in the urinary bladder internal sphincter and in penile erection in the anesthetized cat. Invest Urol 15:404

    Google Scholar 

  7. Hellstrom WJG, Wang R, Kadowitz P, Domer FR (1992) Potassium channel agonists cause penile erection in cats. Int J Impotence Res 4:27

    Google Scholar 

  8. Kielz EA, Blank MA, Bloom SR, Williams G (1987) Studies on intracavernosal VIP levels during pharmacologically induced penile erections. Br J Urol 59:334

    Google Scholar 

  9. Kielz EA, Bloom SR, Williams G (1989) Penile response to intracavernosal vasoactive intestinal polypeptide alone and in combination with other vasoactive agents. Br J Urol 64:191

    Google Scholar 

  10. Lomas GM, Jarow JP (1992) Risk factors for papaverine-induced priapism. J Urol 147:1280

    Google Scholar 

  11. Lue TF, Tanagho EA (1987) Physiology of erection and pharmacological management of impotence. J Urol 137:829

    Google Scholar 

  12. Padma-Nathan H (1990) The efficacy and synergy of polypharmacotherapy in primary and salvage therapy of vasculogenic erectile dysfunction. Int J Impotence Res 2 [Suppl 2]:257

    Google Scholar 

  13. Saenz de Tejada I, Goldstein I, Krane RJ (1988) Local control of penile erection: nerves, smooth muscle and endothelium. Urol Clin North Am 15:9

    Google Scholar 

  14. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA (1989) Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 320:1025

    Google Scholar 

  15. Sidi AA (1988) Vasoactive intracavernous pharmacotherapy. Urol Clin North Am 15:95

    Google Scholar 

  16. Virag R (1982) Intracavernous injection of papaverine for erectile failure. Lancet 2:938

    Google Scholar 

  17. Virag R, Frydman D, Legman M, Virag H (1984) Intracavernous injection of papaverine as a diagnostic and therapeutic method in erectile failure. Angiology 35:79

    Google Scholar 

  18. Weiske WH (1990) Prostaglandin E1 (PGE1) in diagnosis and treatment of erectile dysfunction (ED). Int J Impotence Res 2 [Suppl 2]:234

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology and Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, 70112, New Orleans, LA, USA

    Run Wang, Todd R. Higuera, Suresh C. Sikka, Robert K. Minkes, John A. Bellan, Philip J. Kadowitz, Floyd R. Domer & Wayne J. Hellstrom

Authors
  1. Run Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Todd R. Higuera
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Suresh C. Sikka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robert K. Minkes
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. John A. Bellan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Philip J. Kadowitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Floyd R. Domer
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Wayne J. Hellstrom
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, R., Higuera, T.R., Sikka, S.C. et al. Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside. Urol. Res. 21, 75–78 (1993). https://doi.org/10.1007/BF00295198

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00295198

Key words

Search

Navigation