Summary
The size of the heterochromatic regions of chromosomes 1 and 16 was measured in a Test group of women with histories of recurrent spontaneous abortion and a Control group of fertile women. Measurements were made on Giemsa banded preparations and the euchromatic regions of 1q and 16q were used to correct for between-cell contraction. For each chromosome pair, the larger and smaller chromosome was identified and populations of each were compared between the two subject groups. For chromosome 1, the smaller chromosome of the Test group was significantly smaller than that of the Control group (P< 0.001) and the size of the pair difference was larger in the Test than in the Control group (P< 0.01). For chromosome 16, the smaller chromosome of the Test group was smaller than that of the Control group (5% level).
The interaction of chromosome 1 and chromosome 9 heterochromatin in each individual has been analyzed. The combined score for the smaller chromosome 1 and the larger chromosome 9 shows a bimodal distribution and allows discrimination between the two subject groups. Various possible ways in which this interaction might affect reproductive outcome are discussed.
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References
Atkin NB, Brito-Babapulle V (1981) Heterochromatin polymorphism and human cancer. Cancer Genet Cytogenet 3:261–272
Boué J, Boué A (1973a) Anomalies chromosomiques dans les avortments spontanes. In: Boue and Thibault (eds) Les accidents chromosomiques de la reproduction. I.N.S.E.R.M.: 29–55
Boué J, Boué A (1973b) Chromosomal analysis of two consecutive abortuses in each of 43 women. Humangenetik 19:275–280
Boué J, Taillemite JL, Hazael-Massieux P, Leonard C, Boué A (1975) Association of pericentric inversion of chromosome 9 and reproductive failure in ten unrelated families. Humangenetik 30:217–224
Ford JH (1977) Cytogenetics of infertility and habitual abortion. Records of Adelaide Children's Hospital 1:287–293
Ford JH, Lester P (1978) Chromosomal variants and non-disjunction. Cytogenet Cell Genet 21:300–303
Ford JH, Callen DF, Jahnke AB, Roberts CG (1982) Within pair differences of human chromosome 9 C-bands associated with reproductive loss. Hum Genet 336:1–4
Whang HS, Hamerton JL (1979) C-band polymorphism of chromosomes 1, 9 and 16 in four subgroups of mentally retarded patients and a normal control population. Hum Genet 51:269–275
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Ford, J.H., Callen, D.F., Roberts, C.G. et al. Interactions between C-bands of chromosomes 1 and 9 in recurrent reproductive loss. Hum Genet 63, 58–62 (1983). https://doi.org/10.1007/BF00285399
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DOI: https://doi.org/10.1007/BF00285399