Summary
Units were recorded extracellularly in paravermal cortex (lobule VI) of the cerebellum of chloralose anesthetized cats. Electrical stimulation of the striatum evoked excitation followed by inhibition in these neurons. In addition, the somatosensory properties of these cells were also affected by the striatum. A conditioning-test paradigm (C-T) was used in which conditioning stimulation was applied to the striatum. Test responses were evoked in cerebellar neurons by facial stimulation. As a function of the C-T interval, striatal stimulation could either enhance or suppress the test facial responses. In another procedure, a moveable electrode was used to map the thresholds for affecting the cerebellum from different points in the striatum. The lowest mean threshold was in the putamen followed respectively by the internal capsule and caudate nucleus. Control experiments suggested that striatal effects on the cerebellum were due neither to extra-striatal current spread nor antidromic activation of corticostriatal fibers. These data were discussed with regard to models of striatal motor functioning that indicate a role in postural control and sensory gating.
Similar content being viewed by others
References
Carpenter MB (1959) Lesions of fastigial nuclei in the rhesus monkey. Am J Anat 104: 1–34
Coxe WS, Snider R (1956) Some relationships of caudate nucleus to cerebellum. Fed Proc 15: 42
Eccles JC, Ito M, Szentágothai J (1967) The cerebellum as a neuronal machine. Springer, New York
Fox M, Williams TD (1968) Responses evoked in the cerebellar cortex by stimulation of the caudate in the cat. J Physiol 198: 435–450
Frigyesi TL (1975) Structure-function relationships of the interconnections between the caudate nucleus, globus pallidus, substantia nigra and thalamus. In: Frigyesi TL (ed) Subcortical mechanisms and sensorimotor activities. Hans Huber, Bern, pp 13–46
Gresty MA, Paul DH (1969) Projection of the caudate nucleus on the anterior lobe of the cerebellum of the cat. J Physiol 240: 81–82P
Gresty MA, Paul DH (1975) Responses of fastigial neurons to stimulation of the caudate nucleus in the cat. J Physiol 245: 655–665
Hopkins DA, Niessen LW (1976) Substantia nigra projections to the reticular formation, superior colliculus and central gray in the rat, cat and monkey. Neurosci Lett 2: 253–259
Ito M (1984) The cerebellum and neural control. Raven Press, New York
Kievit J, Kuypers HGJM (1977) Organization of the thalamocortical projections to the frontal lobe in the rhesus monkey. Exp Brain Res 29: 299–322
Laursen AM (1963) Corpus striatum. Acta Physiol Scand 59: Suppl 11
Levine MS, Hull CD, Buchwald NA (1974) Pallidal and entopeduncular intracellular single unit responses to striatal, cortical, thalamic and sensory inputs. Exp Neurol 44: 448–460
Lidsky TI, Labuszewski T, Avitable MJ, Robinson JH (1979) The effects of stimulation of trigeminal sensory afferents on caudate units in cats. Brain Res Bull 4: 9–14
Lidsky TI, Schneider JS, Harper JA (1980) Jaw movements evoked by substantia nigra stimulation: role of extranigral current spread. Brain Res Bull 5: 487–489
Lidsky TI, Manetto C, Schneider JS (1985) Consideration of sensory factors involved in motor functions of the basal ganglia. Brain Res Rev 9: 133–146
Liles SL, Davis GD (1969) Interrelation of caudate nucleus and thalamus in alteration of cortically induced movement. J Neurophysiol 31: 564–573
Manetto C, Lidsky TI (1987) Influences of the basal ganglia on the medullary reticular formation. Neurosci Lett 75: 278–282
Martin JP (1967) The basal ganglia and posture. Lippincott, Philadelphia
Nauta WJH, Mehler WR (1966) Projections of the lentiform nucleus in the monkey. Brain Res 1: 3–42
Newton RA, Price DD (1975) Modulation of cortical and pyramidal tract induced motor responses by electrical stimulation of the basal ganglia. Brain Res 98: 417–440
Ranck JB Jr (1975) Which elements are excited in electrical stimulation of the mammalian central nervous system: a review. Brain Res 98: 417–440
Rinvik E, Grofova I, Ottersen OP (1976) Demonstration of nigrotectal and nigroreticular projections in the act by axonal transport of proteins. Brain Res 112: 388–394
Schell GR, Strick PL (1983) Origin of thalamic input to the supplementary and arcuate premotor areas. Neurosci Abstr 9: 940
Schneider JS (1986) Interactions between the basal ganglia, the pontine parabrachial region and the trigeminal system in cats. Neuroscience 19: 411–425
Schneider JS, Manetto C, Lidsky TI (1985) Substantia nigra projections to the medullary reticular formation. Neurosci Lett 62: 1–6
Sedgwick EM, Williams TD (1967) Responses of single units in the inferior olive to stimulation of the limb nerves, peripheral skin receptors, cerebellum, caudate nucleus and motor cortex. J Physiol (Lond) 189: 261–279
Snider RS, Matti A, Snider SR (1976) Cerebellar pathways to ventral midbrain and nigra. Exp Neurol 53: 714–728
Somona R, Walberg F (1979) The cerebellar projection from the parabrachial nucleus in the cat. Brain Res 172: 144–149
Valenstein ES, Beer B (1961) Unipolar and bipolar electrodes in self-stimulation experiments. Am J Physiol 201: 1181–1186
Waltzer RP, Martin GF (1984) Collateralization of reticulospinal axons from the nucleus reticularis gigantocellularis to the cerebellum and diencephalon. A double labelling study in the rat. Brain Res 293: 153–158
Weinhold PM (1977) The effects of caudate nucleus stimulation upon jaw movements. Ph.D. dissertation SUNY, Stony Brook
Welzl H, Schwarting R, Huston JP (1984). Substantia nigra efferents and afferents in the control of the perioral biting reflex. In: Bandler R (ed) Modulation of sensorimotor activity during alterations in behavioral states. AR Liss, New York, pp 415–430
Whiteside JA, Snider RS (1953) Relation of cerebellum to upper brainstem. J Neurophysiol 16: 397–413
Author information
Authors and Affiliations
Additional information
Supported by NIH grant NS 21418
Rights and permissions
About this article
Cite this article
Manetto, C., Lidsky, T.I. Striatal influences on paravermal cerebellar activity. Exp Brain Res 73, 53–60 (1988). https://doi.org/10.1007/BF00279660
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00279660