Summary
Fibroblasts of patients with Tay-Sachs' and Sandhoff's disease have been fused. After 7 to 22 days in culture hexosaminidase A-activity could be demonstrated in the hybrid cells both electrophoretically and by heat inactivation.
Zusammenfassung
Fibroblasten von Patienten mit Tay-Sachsscher und Sandhoffscher Krankheit wurden fusioniert. 7–22 Tage nach der Fusion ließ sich Hexosaminidase A in den Hybriden elektrophoretisch und durch Hitzeinaktivierung nachweisen.
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References
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Ropers, H.H., Grzeschik, K.H. & Bühler, E. Complementation after fusion of Sandhoff- and Tay-Sachs fibroblasts. Hum Genet 26, 117–121 (1975). https://doi.org/10.1007/BF00278438
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DOI: https://doi.org/10.1007/BF00278438