Summary
We examined the effect of treatment with piroxicam, a nonsteroidal antiinflammatory drug (NSAID), on immunoglobulin (Ig) and IgM-rheumatoid factor (IgM-RF) synthesis in vitro by lymphocytes of patients with rheumatoid arthritis (RA). Oral treatment with piroxicam induced a progressive decrease of spontaneous IgM-RF production by unstimulated lymphocyte cultures during 12 weeks of observation. Also, pokeweed mitogen (PWM)-driven Ig synthesis was significantly diminished and the effect on total IgM production was sustained until the end of the study. This modulation of humoral responses is consistent with the drop in RF sera level. In addition, we also showed that treatment with NSAIDs can decrease RF levels in the synovial space. NSAIDs may have a long-term beneficial effect in patients with RA due to their modulatory role of lymphocyte responses.
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References
Ceuppens JL, Goodwin JS (1982) Endogenous PGE enhances polyclonal immunoglobulin production by tonically inhibiting T cell suppressor activity. Cell Immunol 70:41–54
Ceuppens JL, Rodriguez MA, Goodwin JS (1982) Non-steroidal antiinflammatory agents inhibit the synthesis of IgM-rheumatoid factor. Lancet 6:528–530
Goodwin JS, Ceuppens JL, Rodriguez MA (1983) Administration of non-steroidal antiinflammatory agents in patients with rheumatoid arthritis. Effects on indexes of cellular immune status and serum rheumatoid factor levels. JAMA 250:2485–2488
Forre O, Thoen J, Helgetveit K, Haile Y (1984) Non-steroidal anti-inflammatory drugs in rheumatoid arthritis: effects on clinical parameters and cellular immunity. Inflammation 8 (suppl):S109-S113
De Zubiria RC, Charria A, Lobo Guerrero D (1983) Clinical and laboratory changes produced by Piroxicam in rheumatoid arthritis. Eur J Rheumatol Inflamm 6:56–62
Carty TJ, Stevens JS, Lombardino JG, Parry MJ, Randall MJ (1980) Piroxicam, a structurally novel antiinflammatory compound: mode of prostaglandin synthesis inhibition. Prostaglandins 19:671–682
Ropes MW, Bennet GA, Cobb J, Jessar RA (1958) 1958 revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis 9:175–176
Rodriguez MA, Bankhurst AD, Ceuppens JL, Williams RC Jr (1981) Characterization of the suppressor cell activity in human cord blood lymphocytes. J Clin Invest 68:1577–1585
Rodriguez MA, Baroja ML, Leon-Ponte M, Abadi I (1986) Abnormal immunoglobulin and rheumatoid arthritis and rheumatoid factor synthesis by blood lymphocytes in patients with primary Sjögren's syndrome. Arthritis Rheum 29:1446–1455
Koopman WJ, Schrohenloher RE (1980) A sensitive radioimmunoassay for quantitation of IgM-rheumatoid factors. Arthritis Rheum 23:302–308
Vane RJ (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 231:232–235
Robinson DR, Levine L (1975) Prostaglandin concentrations in synovial fluid in rheumatic diseases: action of indomethacin and aspirin. Prostaglandin synthetase inhibitors. Raven, New York, pp 223–228
Robinson DR, McGuire MB, Bastian D, Kantrowitz F, Levine L (1978) The effects of antiinflammatory drugs on prostaglandin production by rheumatoid synoval tissue. Prostaglandin Med 1:461–477
Wolinsky SI, Goodwin JS, Messner RP, Williams RC Jr (1980) Role of prostaglandin in the depressed cell mediated immune response in rheumatoid arthritis. Clin Immunol Immunopathol 17:31–37
Hasler F, Bluestein HG, Zvaifler NJ, Epstein LB (1983) Analysis of the defects responsible for the impaired regulation of EBV-induced proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin. J Immunol 131:768–772
Vanderhoek JY, Ekborg SL, Bailey JM (1984) Non-steroidal antiinflammatory drugs stimulate 15 lipoxygenase leukotriene pathway in human polymorphonuclear leukocytes. J Allergy Clin Immunol 74 (suppl):412–417
Atluru D, Goodwin JS (1984) Control of polyclonal immunoglobulin production from human lymphocytes by leukotrienes; leukotriene B4 induces an OKT8(+), radio-sensitive suppressor cell from resting, human OKT8 (−) T cells. J Clin Invest 74:1444–1450
Gualde N, Rigaud M, Goodwin JS (1985) Induction of suppressor cells from peripheral blood T cells by 15-hydroxyecosatetranoic acid (15-HPETE). J Immunol 135:3424–3429
Keightley RG, Cooper MD, Lawton AR (1976) The T cell dependence of B cell differentiation induced by pokeweed mitogen. J Immunol 117:1538–1544
Simkin P (1985) Choosing NSAID therapy. An international reappraisal. Adis, Birkenhead, Auckland, New Zealand, p 76
Ceuppens JL, Robayes G, Verdickt W, Vertessen S, Deckmyn H, Dequeker J (1986) Immunomodulatory effect of treatment with Naproxen in patients with rheumatic disease. Arthritis Rheum 29:305–311
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Rodríguez, M.A., Baroja, M.L., Leon-Ponte, M. et al. Down-regulation of immunoglobulin and IgM-rheumatoid factor synthesis by oral treatment of rheumatoid arthritis patients with a nonsteroidal antiinflammatory drug. Rheumatol Int 8, 81–86 (1988). https://doi.org/10.1007/BF00271839
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DOI: https://doi.org/10.1007/BF00271839