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Interleukin-1-like activities in synovial fluids of patients with rheumatoid arthritis and traumatic synovitis

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Summary

Interleukin-1 (Il-1)-like activity in biological fluids was measured by their ability to rectify the Il-1-dependent lymphokine production of highly purified T lymphocytes to a recall antigen. Il-1-like activity was found in 9 of 11 synovial fluid (SF) specimens from patients with rheumatoid arthritis (RA) but only in 2 of 11 paired RA sera. In traumatic synovitis, low Il-1-like activity was recorded in 5 of 9 SF specimens, and a similar low activity was found in sera of 4 of these patients. The Il-1-like activity was partly absorbed by an anti-Il-1 antibody. The presence of Il-1 in the SF of patients with RA suggests in vivo activation of monocytes/macrophages.

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Authors and Affiliations

  1. Laboratory of Medical Immunology, Department of Medicine TA, 7544, Rigshospitalet University Hospital, 20 Tagensvej, DK-2200, Copenhagen N, Denmark

    K. Bendtzen, J. Petersen, J. Halkjær-Kristensen & T. Ingemann-Hansen

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  1. K. Bendtzen
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  2. J. Petersen
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  3. J. Halkjær-Kristensen
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  4. T. Ingemann-Hansen
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Bendtzen, K., Petersen, J., Halkjær-Kristensen, J. et al. Interleukin-1-like activities in synovial fluids of patients with rheumatoid arthritis and traumatic synovitis. Rheumatol Int 5, 79–82 (1985). https://doi.org/10.1007/BF00270301

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  • DOI: https://doi.org/10.1007/BF00270301

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