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Phase II study of combination bleomycin, vincristine and high-dose methotrexate (BOM) with leucovorin rescue in advanced squamous cell carcinoma of the anal canal

  • Original Articles
  • Combination Therapy, Squamous Carcinoma
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Summary

Fifteen patients with advanced squamous cell carcinoma of the anal canal were treated with a combination of bleomycin, vincristine, and high-dose methotrexate (BOM) with leucovorin rescue. Three out of twelve patients with measurable disease had objective responses of 1, 2, and 5 months. Five of the fifteen patients had severe or life-threatening complications as a result of this treatment regimen. The narrow therapeutic index of the BOM therapy makes it a less than ideal drug combination for the treatment of advanced squamous cell carcinoma of the anal canal.

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Authors and Affiliations

  1. Department of Surgical Oncology, Roswell Park Memorial Institute, 666 Elm Street, 14263, Buffalo, NY, USA

    Nils Wilking, Nicholas Petrelli, Lemuel Herrera & Arnold Mittelman

Authors
  1. Nils Wilking
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  2. Nicholas Petrelli
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  3. Lemuel Herrera
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  4. Arnold Mittelman
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Additional information

Aided by Grant JFCF 793, American Cancer Society, New York, New York

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Wilking, N., Petrelli, N., Herrera, L. et al. Phase II study of combination bleomycin, vincristine and high-dose methotrexate (BOM) with leucovorin rescue in advanced squamous cell carcinoma of the anal canal. Cancer Chemother. Pharmacol. 15, 300–302 (1985). https://doi.org/10.1007/BF00263905

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  • DOI: https://doi.org/10.1007/BF00263905

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