Abstract
An optimized synthesis of 18F-labelled 5-fluorouracil (5-FU) is described. The biodynamics of this radiopharmaceutical were studied in nude mice bearing a 5-FU sensitive (colon 38 carcinoma) or a 5-FU resistant (R1-rhabdomyosarcoma) tumour. It was found that not the initial tumour uptake, but the efflux of the 18F activity from the tumour was correlated with the 5-FU sensitivity of the tumour.
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Visser, G.W.M., Gorree, G.C.M., Braakhuis, B.J.M. et al. An optimized synthesis of 18F-labelled 5-fluorouracil and a reevaluation of its use as a prognostic agent. Eur J Nucl Med 15, 225–229 (1989). https://doi.org/10.1007/BF00257538
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DOI: https://doi.org/10.1007/BF00257538