Abstract
A patient with recurrent C-cell carcinoma of the thyroid is presented. Tumor masses and metastatic lymph nodes were detected by 99mTc-DPD on a preoperative bone scan. In contrast to other causes of extraosseous accumulation of bone-seeking phosphonates, the high affinity of amyloid is the main factor in the case of C-cell carcinoma. Because amyloid is the typical histochemical sign of the carcinoma type, imaging with phosphonates is expected to be another specific diagnostic procedure in addition to calcitonin measurements. The role of other markers in thyroid carcinomas is discussed.
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References
Arnal-Monreal FM, Goltzman D, Knaack J, Wang N, Huang S (1977) Immunohistologic study of thyroidal medullary carcinoma and pancreatic insulinoma. Cancer 40:1060–1070
Block MA, Jackson CE, Tashjian AH (1978) Management of occult medullary thyroid carcinoma. Arch Surg 113:368–372
Deftos LJ (1978) Calcitonin in clinical medicine. In: Stollerman GH (ed) Advances in internal medicine, vol. 23, Chicago, Year Book, pp 153–193
Fukuchi M, Tachibana K, Kuwata K, Nishikawa A, Hyodo K, Okamato E, Nagai K (1978) Thallium-201 imaging in thyroid carcinoma — Appearance of a lymph-node metastasis. J Nucl Med 19:195–196
Glenner GG (1980) Amyloid deposits and amyloidosis. N Engl J Med 302:1283–1293, 1333–1343
Keiser HR, Beaven MA, Doppman J, Wells S jr, Buja LM (1973) Sipple's syndrome: medullary thyroid carcinoma, pheochromocytoma, and parathyroid disease. Ann Int Med 78:561–579
Kula RW, Engel WK, Line BR (1977) Scanning for soft tissue amyloid. Lancet 1:92–93
Ljungberg O (1966) Medullary carcinoma of the human thyroid gland. Autoradiographic localization of radioiodine. Acta Pathol Microbiol Scand 68:476–480
Pepys MP, Dash AC, Munn EA, Feinstein A, Skinner M, Cohen AS, Gewurz H, Osmand AP, Painter RH (1977) Isolation of amyloid P complement (protein AP) from normal serum as a calcium-dependent binding protein. Lancet I:1029–1031
Schümichen C, Hoffmann G (1978) Extraossäre Anreicherung und pitfals in der Skelettszintigraphie mit osteotropen Substanzen. Der Nuklearmediziner 1:22–30
Silberstein E, Francis MD, Tofe AJ, Slough CL (1975) Distribution of 99mTc-Sn diphosphonate and free 99mTc pertechnetate in selected soft and hard tissue. J Nucl Med 16:58–61
Sommer B, Heidenreich P, Backmann R (1980) Extraossäre Anreicherung von 99mTc-MDP bei generalisierter sekundärer Amyloidose. Fortschr Röntgenstr 133:213–215
Torizuka K, Mori T, Odori T, Endo K, Ikekubo K, Konishi J, Morita R (1976) 99mTc Bleomycin scintigraphy in the diagnosis of thyroid cancers. In: Robbins J and Braverman LE (eds) Thyroid research, Elsevier, New York, pp 571–574
VanAntwerp JD, O'Mara RE, Pitt MJ, Walsh S (1975) Technetium-99m-diphosphonate accumulation in amyloid. J Nucl Med 16:238–240
Vanek JA, Cook SA, Bukowski RM (1977) Hepatic uptake of Tc99m-labeled diphosphonate in amyloidosis: case report. J Nucl Med 18:1086–1088
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Reuter, E., Bethge, N., Matthes, M. et al. 99mTc-phosphonates for imaging of amyloid in C-cell carcinoma. Eur J Nucl Med 8, 398–400 (1983). https://doi.org/10.1007/BF00253215
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DOI: https://doi.org/10.1007/BF00253215