Skip to main content
Log in

Immunohistochemical profile of ovarian inclusion cysts in patients with and without ovarian carcinoma

  • Papers
  • Published:
The Histochemical Journal Aims and scope Submit manuscript

Summary

The expression of cytokeratin, epithelial membrane antigen, Leu-M1, B72.3, carcinoembryonic antigen, human placental lactogen, proliferating cell nuclear antigen, p53, and ovarian carcinoma-associated antigen OC-125 was evaluated in inclusion cysts in contralateral ovaries of patients with unilateral ovarian carcinoma. The findings were compared with the findings in inclusion cysts in ovaries of patients without ovarian carcinoma. Although there was more frequent expression of tumour markers B72.3 and CEA in patients with ovarian carcinoma, these differences did not reach statistical significance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Aure, J. C., Hoeg, K. & Kolstad, P. (1971) Clinical and histological studies of ovarian carcinoma: long-term follow-up of 990 cases. Obstet. Gynecol. 37, 1–9.

    Google Scholar 

  • Blaustein, A., Kaganowicz, A. & Wells, J. (1982) Tumor markers in inclusion cysts of the ovary. Cancer 49, 722–6.

    Google Scholar 

  • Boerman, O. C., VanNiekerk, C. C., Makkink, K., Hanselaar, T. G., Kenemans, P. & Poels, L. G. (1991) Comparative immunohistochemical study of four monoclonal anti-bodies directed against ovarian carcinoma-associated antigens. Int. J. Gynecol. Pathol. 10, 15–25.

    Google Scholar 

  • Czernobilsky, B. (1987) Common epithelial tumors of the ovary. In Blaustien's Pathology of the Female Genital Tract (edited by Kurman, R. D.), 3rd edn. New York: Springer-Verlag.

    Google Scholar 

  • Demopoulos, R. I., Bigelow, B., Blaustein, A. et al. (1984) Characterization and survival of patients with serous cystadenocarcinoma of the ovaries. Obstet. Gynecol. 64, 557–63.

    Google Scholar 

  • Eccles, D. M., Brett, L., Lessells, A., Gruber, L., Lane, D., Steel, C. M. & Leonard, R. C. (1992) Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma. Br. J. Cancer 65, 40–4.

    Google Scholar 

  • Hertig, A. T. & Gore, H. M. (1958) Ovarian cystomas of germinal epithelial orgin. A histogenetic classification. Rocky Mountain Med. J. 55, 47–50.

    Google Scholar 

  • Kerns, B. J., Jordan, P. A., Moore, M. B., Humphrey, P. A., Berchuck, A., Kohler, M. F., Bast, R. C. Jr., Iglehart, J. D. & Marks, J. R. (1992) p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry. J. Histochem. Cytochem. 40, 1047–51.

    Google Scholar 

  • Kihana, T., Tsuda, H., Teshima, S., Okada, S., Matsuura, S. & Hirohashi, S. (1992) High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidy. Jap. J. Cancer Res. 83, 978–84.

    Google Scholar 

  • McKay, D. G. (1962) The origin of ovarian tumors. Clin. Obstet. Gynecol. 5, 1181–98.

    Google Scholar 

  • Manivel, J. C., Wick, M. R., Coffin, C. M. & Dehner, L. P. (1989) Immunohistochemistry in the differential diagnosis in the second-look operation for ovarian carcinomas. Int. J. Gynecol. Pathol. 8, 103–13.

    Google Scholar 

  • Mittal, K. R., Zeleniuch-Jacquotte, A., Cooper, J. L. & Demopoulos, R. I. (1993) Contralateral ovary in unilateral ovarian carcinoma: a search for pre-neoplastic lesions. Int. J. Gynecol. Pathol. 12, 59–63.

    Google Scholar 

  • Monench, L. M. (1933) A clinical study of 403 cases of adenocarcinoma of the ovary. Am. J. Obstet. Gynecol. 26, 22–8.

    Google Scholar 

  • Munnell, E. W. (1968) The changing prognosis and treatment in cancer of the ovary: a report of 235 patients with primary ovarian carcinoma 1952–1961. Am. J. Obstet. Gynecol. 100, 790–805.

    Google Scholar 

  • Munnell, E. W. (1969) Is conservative therapy ever justified in Stage 1(1A) cancer of the ovary? Am. J. Obstet. Gynecol. 103, 641–69.

    Google Scholar 

  • Munnell, E. W. & Taylor, H. C. Jr. (1949) Ovarian carcinoma: a review of 200 primary and 51 secondary cases. Am. J. Obstet. Gynecol. 58, 943–59.

    Google Scholar 

  • Parker, R. T., Parker, C. H. & Wilbanks, G. D. (1970) Cancer of the ovary: survival studies based upon operative therapy, chemotherapy, and radiotherapy. Am. J. Obstet. Gynecol. 108, 878–88.

    Google Scholar 

  • Plaxe, S. C., Deligdish, L., Dottino, P. R. & Cohen, C. J. (1990) Ovarian intraepithelial neoplasia demonstrated in patients with Stage 1 ovarian carcinoma. Gynecol. Oncol. 38, 367–72.

    Google Scholar 

  • Radisavljevic, S. V. (1977) The pathogenesis of ovarian inclusion cysts and cystomas. Obstet. Gynecol. 49, 424–9.

    Google Scholar 

  • Scully, R. E. (1977) Ovarian tumors: a review. Hum. Pathol. 87, 686–720.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mittal, K.R., Goswami, S. & Demopoulos, R.I. Immunohistochemical profile of ovarian inclusion cysts in patients with and without ovarian carcinoma. Histochem J 27, 119–122 (1995). https://doi.org/10.1007/BF00243906

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00243906

Keywords

Navigation