Summary
The present experiments tested the sensitivity of theta activity to ACTH 4–10 a peptide known to facilitate the maintenance of conditioned behaviors. Hippocampal theta activity was induced by electrical stimulation of the reticular formation in freely moving rats. The administration of ACTH 4–10 produced a typical 0.5 c/s shift in dominant frequency and an increase in 7.5–9.0 c/s components of induced theta activity. The effects were maximal between 60–120 min after subcutaneous injection and lasted several hours. The fact, that a similar effect could be obtained by an increase in stimulus intensity suggests an elevated excitability in the theta generating system in the presence of the peptide. The possible significance of this finding for the maintenance of learned behavior is discussed.
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Arnolds, D., Lopes da Silva, F.H., Kamp, A., Aitink, W.: Motor acts and firing of reticular neurons correlated with operantly reinforced hippocampus theta shift. Abstract VIth Annual Meeting of the European Brain and Behavior Society, Paris, September 19–21 (1974)
Black, A.H., Young, G.A.: The electrical activity of the hippocampus and cortex in dogs operantly conditioned to move and to hold still. J. comp. physiol. Psychol. 79, 128–141 (1972)
Bloch, V., Deweer, B., Hennevin, E.: Suppression de l'amnésie rétrograde et consolidation d'un apprentissage à essai unique par stimulation réticulaire. Physiol. Behav. 5, 1235–1241 (1970)
Brown, B.B.: Frequency and phase of hippocampal theta activity in the spontaneously behaving cat. Electroenceph. clin. Neurophysiol. 24, 53–62 (1968)
De Wied, D.: Effects of peptide hormones on behaviour. In: Frontiers in Neuroendocrinology. (Eds. W.F. Ganong, L. Martini). pp. 97–140. New York: Oxford University Press 1969
De Wied, D.: Pituitary adrenal system hormones and behavior. In: Neurosciences Third Study Program. (Eds. F.O. Schmitt, F.G. Worden). pp. 653–666. Cambridge: MIT Press 1974
Green, J.D., Arduini, A.: Hippocampal electrical activities in arousal. J. Neurophysiol. 17, 533–537 (1954)
Horowitz, J.M., Salen, M.A., Karem, R.D.: Correlation of hippocampal theta rhythm with changes in cutaneous temperature. Amer. J. Physiol. 227, 635–642 (1974)
Kesner, R.P., Conner, H.S.: Effect of electrical stimulation of rat limbic system and midbrain reticular formation upon short- and long-term memory. Physiol. Behav. 12, 5–12 (1974)
Klemm, W.R.: Correlation of hippocampal theta rhythm, muscle activity, and brain stem reticular formation activity. Comm. Behav. Biol. 5, 147–151 (1970)
Klemm, W.R.: Theta rhythm and memory. Science 176, 1444 (1972a)
Klemm, W. R.: Effects of electrical stimulation of the brain stem reticular formation on hippocampal theta activity in unanesthetized cervical -and midbrain-transected rats. Brain Res. 41, 331–344 (1972b)
Klemm, W.R.: Ascending and descending influences in the brain stem reticulum: A re-examination. Brain Res. 36, 444–452 (1972c)
Korányi, L., Beyer, C., Guzman-Flores, C.: Effect of ACTH and hydrocortisone on multiple unit activity in the forebrain and thalamus in response to reticular stimulation. Physiol. Behav. 7, 331–335 (1971)
Landfield, P.W., McGaugh, J.L., Tusa, R.J.: Theta rhythm: A temporal correlate of memory storage processes in the rat. Science 175, 87–89 (1972)
Lindslay, D.F., Barton, R.J., Atkins, R.J.: Effect of subthalamic lesion on peripheral and central arousal threshold in cat. Exp. Neurol. 26, 109–119 (1970)
Longo, V.G.: Electroencephalographic atlas for pharmacological research. In: Rabbit Brain Research, Vol. II, p. 129. Amsterdam: Elsevier 1962
Longo, V.G., Loizzo, A.: Effects of drugs on the hippocampal O-rhythm; possible relationships to learning and memory processes. In: Pharmacology and the Future Man, Vol. 4, pp. 46–54. Proceedings 5th Int. Congr. Pharmacology, San Francisco 1972. Basel: S. Karger 1973
McGaugh, J.L.: Drug facilitation of learning and memory. Ann. Rev. Pharmacol. 13, 229–241 (1973)
Miller, L.H., Kastin, A. J., Sandman, C.A., Fink, M., Veen, J.W. van: Polypeptide influence on attention, memory and anxiety in man. Pharmacol. Biochem. Behav. 2, 663–668 (1974)
Petsche, H., Stumpf, Ch.: Topographic and toposcopic study of origin and spread of the regular synchronized arousal patterns in the rabbit. Electroenceph. clin. Neurophysiol. 12, 589–600 (1960)
Pfaff, D.W., Silva, M.T.A., Weiss, J.M.: Telemetered recording of hormone effects on hippocampal neurons. Science 172, 394–398 (1971)
Sandman, C.A., Miller, L.H., Kastin, A.J., Schally, A.V.: Neuroendocrine influence on attention and memory. J. comp. physiol. Psychol. 80, 54–58 (1972)
Sawyer, Ch., Kawakami, M., Meyerson, B., Whitmoyer, D.I., Lilley, J.: Effects of ACTH, dexamethasone and asphyxia on electrical activity of the rat hypothalamus. Brain Res. 10, 213–226 (1968)
Van Wimersma Greidanus, Tj.B., De Wied, D.: Effects of systemic and intracerebral administration of two opposite acting ACTH related peptides on extinction of conditioned avoidance behavior. Neuroendocrinology 7, 291–301 (1971)
Vanderwolf, C.H.: Limbic-diencephalic mechanism of voluntary movement. Psychol. Rev. 78, 83–113 (1971)
Vanderwolf, C.H.: Neocortical and hippocampal activation in relation to behavior: Effects of atropine, eserine, phenothiazines and amphetamine. J. comp. physiol. Psychol. 88, 300–323 (1975)
Weiss, J.M., McEwen, B.S., Silva, M.T., Kalkut, M.: Pituitary-adrenal alteration and fear responding. Amer. J. Physiol. 218, 864–868 (1970)
Winson, J.: Patterns of hippocampal theta rhythm in the freely moving rat. Electroenceph. clin. Neurophysiol. 36, 291–301 (1974)
Whishaw, I.Q.: Hippocampal electroencephalographic activity in the Mongolian gerbil during natural behaviours and wheel running and in the rat during wheel running and conditioned immobility. Canadian J. Psychol. 26, 219–239 (1972)
Whishaw, I.Q., Vanderwolf, C.H.: Hippocampal EEG and behavior: changes in amplitude and frequency of RSA (theta rhythm) associated with spontaneous and learned movement patterns in rats and cats. Behav. Biol. 8, 461–484 (1973)
Zimmermann, E., Krivoy, W.: Antagonism between morphine and the polypeptides ACTH, ACTH 1–24 and β-MSH in the nervous system. In: Drug Effects on Neuroendocrine Regulation, Progress in Brain Research, Vol. 39, pp. 383–394. (Eds. E. Zimmermann, W.H. Gispen, B.H. Marks, D. de Wied). Amsterdam: Elsevier 1973
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Urban, I., de Wied, D. Changes in excitability of the theta activity generating substrate by ACTH 4–10 in the rat. Exp Brain Res 24, 325–334 (1976). https://doi.org/10.1007/BF00235019
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DOI: https://doi.org/10.1007/BF00235019