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Are interactions with phospholipids responsible for pharmacological activities of cardiotoxins?

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Summary

Cardiotoxins are small basic proteins (7 000 daltons) that are found in the venoms of Elapidae snakes. Although they are structurally close to a-neurotoxins present in the same secretions, their activity is related to their ability to interact with every cell membrane inducing, near micromolar concentration, the modification of its biological properties and/or physical structure. The mode of action of cardiotoxins, on a molecular level, is still under investigation. However, lipid-protein interactions are more and more involved in their binding to membrane and in their activities. Using new experimental data a better definition of phospholipid cardiotoxin interaction is arrived at and a tentative molecular explanation of the pharmacological activities of these proteins is presented and discussed.

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Authors and Affiliations

  1. Laboratoire de Biochimie, Faculte de Médecine, I.N.S.E.R.M. U.172 and S. C. 10, Secteur Nord, Bd. P. Dramard, 13326, Marseille Cedex 15, France

    P. Bougis, M. Tessier, J. Van Rietschoten & H. Rochat

  2. C. N. R. S., Centre de Recherche Paul Pascal, Domaine Universitaire, 33405, Talence, France

    J. F. Faucon & J. Dufourcq

Authors
  1. P. Bougis
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  2. M. Tessier
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  3. J. Van Rietschoten
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  4. H. Rochat
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  5. J. F. Faucon
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  6. J. Dufourcq
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Bougis, P., Tessier, M., Van Rietschoten, J. et al. Are interactions with phospholipids responsible for pharmacological activities of cardiotoxins?. Mol Cell Biochem 55, 49–64 (1983). https://doi.org/10.1007/BF00229242

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  • DOI: https://doi.org/10.1007/BF00229242

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