Abstract
Color vision tests and electrooculography (EOG) were performed in 6 male and 2 female healthy young trichromatic volunteers between 60 and 130 min after finishing consumption of ethyl alcohol leading to blood levels of approximately 0.07% to 0.16%. The average number of errors in the desaturated Panel D-15 arrangement test rose from 0.86 to 2.0; the average error score in the Farnsworth-Munsell 100-Hue test rose from 26 to 79. The axis of errors in both tests was clearly tritanopic and tetartanopic, pointing to a specific effect of ethyl alcohol on the function of blue-sensitive cones and/or their interaction with longer wavelength-sensitive cones.
Ethyl alcohol decreased the size of the light-peak, apparently in a dose-dependent fashion, in each of the 16 eyes by values between 3% and 79%. The effect of alcohol on the EOG light peak was stronger between 30 and 95 min (23% decrease in average) than between 95 and 130 min (14% decrease) after the finish of alcohol administration.
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References
Dodt E and Baier M (1984) Area-luminance relationship for a constant light peak of the standing potential in the human eye. Ophthalmologica 188:232–238
Gilg, T, Liebhardt E, Schuller E and Riedel K (1984) Alkoholbedingte Wahrnehmungs-störungen im peripheren Gesichtsfeld. Blutalkohol 21:235–249
Gramberg-Danielsen B (1965) Farbenuntüchtigkeit und Straßenverkehr, Z Verk-Med 11:1–12
Kitahara K (1984) An analysis of the Farnsworth-Munsell 100-Hue test. In: Color Vision Deficiences VII, (ed) Verriest G. Hague, Boston: Dr W Junk, Publishers 247:251
Knave B, Persson HE and Nilsson SEG (1974): A comparative study on the effects of barbiturate and ethyl alcohol on retinal function with special reference to the c-wave of the electroretinogram and standing potential of the sheep eye. Acta Ophthalmol (Kbh) 52:254–259
Koen AI and Shaw CR (1966) Retinol and alcohol dehydrogenases in retina and liver. Biochim Biophys Acta 128:48–54
Köllner H (1912) Die Störungen des Farbensinns. Karger, Berlin
Peters HB (1942) Changes in color fields occasioned by experimentally induced intoxication. J Appl Psychol 26:692–701
Pokorny J, Smith V, Verriest B and Pinckers AJLG (eds) (1979) Congenital and Acquired Color Vision Defects. New York: Grune and Stratton
Remky H (1956) Augenärztliche Befunde bei akuter Alkoholeinwirkung. In: Der Verkehrsunfall, eds: Laves W, Bitzel F and Berger E, pp 221
Riedel KG, Gilg T and Liebhardt E (1985) Wahrnehmungsstörungen im peripheren Gesichtsfeld unter Alkoholeinflu ß. Klin Monatsbl Augenheilk 186:279–283
Russell RM, Carney EA, Felock K, Garret M and Karwoski P (1980) Acute ethanol administration causes transient impairment of blue-yellow color vision. Alcoholism Clin Exp Res 4:396–399
Sakuma Y (1973) Studies on color vision abnormalities in subjects with alcoholism. Ann Ophthalmol 5:1277–1292
Sassoon HF, Wise JB and Watson JI (1970) Alcoholism and color vision: Are there familiar links? Lancet 2:367–368
Skoog K-O (1974) The c-wave of the human dc registered ERG. III. Effects of ethyl alcohol on the c-wave. Acta Ophthalmol 52:913–923
Skoog K-O, Textorius O and Nilsson SEG (1975) Effects of ethyl alcohol on the directly recorded standing potentials of the human eye. Acta Ophthalmol 53:710–720
Skoog K-O, Welinder W and Nilsson SEG (1978) The influence of ethyl alcohol on slow off-responses in the human dc registered electroretinogram. Vision Res 18:1041–1044
Steinberg RH, Linsenmeier RA and Griff ER (1985) Retinal pigment epithelial cell contributions to the electroretinogram and electrooculogram. Progr Retinal Res 4:33–66
Wald G and Hubbard R (1949) The reduction of retinene 1 to Vitamin A1 in vitro. J Gen Physiol 32:367–389
Wallgren H and Barry H (1970) Actions of Alcohol, Vol 1. Amsterdam, London, Elsevier Publishing Company. pp 289–292
Zrenner E (1982) Electrophysiological characteristics of the blue-sensitive mechanism: Test of a model of cone interaction under physiological and pathological conditions. Doc Ophthalmol Proc Series 33:103–125
Zrenner E (1983) Neurophysiological aspects of color vision in primates. Studies of Brain Function Series, Vol 9. Berlin, New York: Springer
Zrenner E, Kramer W, Bittner Ch, Bopp M and Schlepper M (1982) Rapid effects on color vision, following intravenous injections of a new, non-glycoside-positive inotropic substance (AR-L 115 BS) Doc Ophthalmol Proc Series 33:507–521
Zrenner E, Nowicki J and Adamczyk R (1986) Cone function and cone interaction in hereditary degenerations of the central retina. Docum Ophthalmol 62:5–12
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Zrenner, E., Riedel, K.G., Adamczyk, R. et al. Effects of ethyl alcohol on the electrooculogram and color vision. Doc Ophthalmol 63, 305–312 (1986). https://doi.org/10.1007/BF00220220
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DOI: https://doi.org/10.1007/BF00220220