Skip to main content

Advertisement

SpringerLink
Log in

Seroepidemiological correlations of antibodies to human herpesviruses and human immunodeficiency virus type 1 in African patients

  • Published:
European Journal of Epidemiology Aims and scope Submit manuscript

Abstract

A seroepidemiological evaluation of the humoral immune response against human herpes viruses was carried out in patients with and without HIV infection in Tanzania to study the role of these viruses as a cofactor in AIDS. Serum specimens were obtained from 321 outpatients and 100 healthy schoolchildren of a rural population in the Kagera Region, Tanzania, and from 149 inpatients of an urban population in Dar-es-Salaam, Tanzania. The data were analysed by logistic models taking into account demographic variables. The data obtained revealed no differences in the prevalence of antibodies to human herpes viruses between the different groups. Therefore, our study under the present conditions and the observed stages of AIDS does not suggest an influence of HIV infection on human herpesvirus infection or serologic response.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. AblashiD. V., JosephsS.F., BuchbinderA., HellmanK., NakamuraS., LlanaT., LussoP., KaplanM., DahlbergJ., MemonS., ImamF., AblashiK.L., MarkhamP.D., KramarskyB., KruegerG.R.F., BiberfeldP., Wong-StaalF., SalahuddinS.Z. and GalloR.C. (1988): Human B-lymphotropic virus (human herpesvirus-6)- J. Virol. Meth. 21: 29–48.

    Google Scholar 

  2. Briggs M., Fox J. and Tedder R.S. (dy1988): Age prevalence of antibody to human herpesvirus 6 -Lancet 1058–1059.

  3. Brown N.A., Sumaya CV, Liu C.-R., Ench Y., Kovacs A., Coronesi M. and Kaplan M.H. (1988): Fall in human herpesvirus 6 seropositivity with age - Lancet 396.

  4. BuchwaldD., SullivanJ.L. and KomaroffA.L. (1987): Frequency of chronic active Epstein-Barr Virus Infection in a General Medical Practice - JAMA 257: 2303–2307.

    Google Scholar 

  5. DuclosH., ElfassiE., MichelsonS., Arenzana-SeisdedosF., Munier and VirelizierJ.L. (1989): Cytomegalovirus Infection and Trans-Activation of HIV-1 and HIV-2 LTRs in Human Astrocytoma Cells- AIDS RESEARCH AND HUMAN RETROVIRUSES 5: 217–224.

    Google Scholar 

  6. Efstathiou S., Gompels U.A., Craxton M.A., Honess R. W. and Ward K. (1988): DNA homology between a novel human herpesvirus (HHV-6) and human cytomegalovirus - Lancet 63–64.

  7. Fox J., Briggs M. and Tedder R.S. (1988): Antibody to human herpesvirus 6 in HIV-1 positive and negative homosexual men - Lancet 396–397.

  8. GendelmannHE., PhelpsW., FeigenbaumL., OstroveJ.M., AdachiA., HowleyP.M., KhouryG., GinsbergH.S. and MartinM.A. (1986): Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses - Proc. Natl. Acad. Sci. USA 83: 9759–9763.

    Google Scholar 

  9. HinumaY., KohnM., YamaguchiJ., WudarskiD.J., BlakesleeJ.R.Jr. and GraceJ.T.Jr. (1967): Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line - J. Virol. 1: 1045–1051.

    Google Scholar 

  10. Holmberg S.D., Gerber A.R., Stewart JA., Lee EK, O'Malley P.M. and Nahmias A.J. (1988): Herpesviruses as co-factors in AIDS - Lancet 746–747.

  11. Holmberg S.D., Lopez C.A., Byers R.H., Rutherford G.W. and Jaffe H.W. (1989): Human herpesvirus-6 (HHV-6) in a cohort of homosexual men. Presented at the 5th International Conference on AIDS, Montreal, June, 4–9, 1989, abstract.

  12. HuemerP.H., LarcherC., WachterH. and DierichM.P. (1989): Prevalence of Antibodies to Human Herpesvirus 6 in Human Immunodeficiency Virus 1 Seropositive and Negative Intravenous Drug Addicts -J. Infect. Dis. 160: 549–550.

    Google Scholar 

  13. Knowles W.A. and Gardner S.D. (1988): High prevalence of antibody to human herpesvirus-6 and seroconversion associated with rash in two infants -Lancet 911–913.

  14. Krueger G.R.F. and Ablashi D. Y. (1987): Human B-lymphotropic virus in Germany - Lancet 694.

  15. KruegerG.R.F., KochB., RamonA., AblashiD.V., SalahuddinS.Z., JosephsS.F., StreicherHZ., GalloR.C. and HabermannU.(1988): Antibody prevalence to HBLV (HHV-6) and suggestive pathogenicity in the general population and in patients with immunodeficiency syndromes - J. Virol. Meth. 21: 125–131.

    Google Scholar 

  16. KruegerG.R.F. and RamonA. (1988): Overview of immunopathology of chronic active herpesvirus infection - J. Virol. Meth. 21: 11–18.

    Google Scholar 

  17. Larcher C., Huemer H.P., Margreiter R. and Dierich M.P. (1988): Serological crossreaction of human herpesvirus-6 with cytomegalovirus - Lancet 963–964.

  18. LennetteET., HalonenP. and MurphyF.A. (1988): Laboratory Diagnosis of Infectious Diseases -Springer, New York 237–238.

    Google Scholar 

  19. Levy J.A., Ferro F., Greenspan D. and Lennette ET. (1990): Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population -Lancet 1047–1050.

  20. LindeA., DahlH., WahrenB., FridellE., SalahuddinS.Z. and BiberfeldP. (1988): IgG antibodies to human herpesvirus-6 in children and adults both in primary Epstein-Baff virus and cytomegalovirus infections - J. Virol. Meth. 21: 117–123.

    Google Scholar 

  21. LussoP., EnsoliB., MarkhamP.D., AblashiD. V., SalahuddinS.Z., TschachlerE., Wong-StaalF. and GalloR.C. (1989): Productive dual infection of human CD4 positive T-lymphocytes by HIV-1 and HHV-6- Nature 337:370–373.

    Google Scholar 

  22. MenezesJ., LeiboldW., KleinG. and ClementsG. (1975): Establishment and characterisation of an Epstein-Barr virus (EBV)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma - Biomedicine 22: 276–284.

    Google Scholar 

  23. Morris D.J., Littler E., Jordan D. and Arrand J.R. (1988): Antibody responses to human herpesvirus 6 and other herpesviruses - Lancet 1425–1426.

  24. MoscaJ.D., BednarikD.P., RajN.B.K., RosenCA., SodroskiJ.C, HaseltineW.A., HaywardG.S. and PithaP.M. (1987): Activation of human immunodeficiency virus by herpesvirus infection: Identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1 - Proc. Natl. Acad. Sci. 84: 7408–7412.

    Google Scholar 

  25. NabelG.J., RiceS.A., KnipeD.M. and BaltimoreD. (1988): Alternative Mechanisms for Activation of Human Immunodeficiency Virus Enhancer in T cells- Science 239: 1299–1302.

    Google Scholar 

  26. Pulvertaft R.J.Y. (1964): Cytology of Burkitt's tumor (African lymphoma) - Lancet 238–240.

  27. RahmannM.A., KingsleyL.A., BreinigM.K., HoM., ArmstrongJ.A., AtchisonR. W., LyterD. W. and RinaldoCR.Jr. (1989): Enhanced Antibody Responses to Epstein-Barr Virus in HIV-infected Homosexual Men - J. Infect. Dis. 159: 472–479.

    Google Scholar 

  28. RinaldoC.R.Jr., KingsleyL.A., LyterD. W., RabinB.S., AtchisonR.W., BodnerA.J., WeissS.H. and SaxingerW.C. (1986): Association of HTLV-III with Epstein-Barr Virus Infection and Abnormalities of T Lymphocytes in Homosexual Men - J. Infect. Dis. 154: 556–561.

    Google Scholar 

  29. SalahuddinS.Z, AblashiD. V., MarkhamP.D., JosephsS.F., SturzeneggerS., KaplanM., HalliganG., BiberfeldP., Wong-StaalF., KramarskyB. and GalloR. C. (1986): Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders - Science 234: 596–600.

    Google Scholar 

  30. SAS Institute Inc. (1985): SAS User's Guide: Basics, Version 5 - Edition, Cary, NC: SAS Institute Inc.

    Google Scholar 

  31. SaxingerC., PoleskyH., EbyN., GruffermannS., MurphyR., TegtmeirG., ParekhV., NemonS. and HungC. (1988): Antibody reactivity with HBLV (HHV-6) in U.S. populations - J. Virol. Meth. 21: 199–208.

    Google Scholar 

  32. Schwinn A., Rethwilm A., Essers S., Borisch B. and ter Meulen V. (1989): Interaction of HIV-1 and HHV-6. -2 Statusseminar des BMFT, Bonn, FRG, 12-14.10.1989.

  33. SiekevitzM., JosephsS.F., DukovichM., PfefferN., Wong-StaalF., GreeneW. C. (1987): Activation of the HIV-1 LTR by T Cell Mitogens and the Trans-Activator Protein of HTLV I - Science 238: 1575–1578.

    Google Scholar 

  34. SpiraT.J., BozemannL.H., SanderlinK.C, WarfieldD.T., FeorinoP.M., HolmanR.C, KaplanJ.E, FishbeinD.B. and LopezC. (1990): Lack of Correlation between Human Herpesvirus-6 Infection and the Course of Human Immunodeficiency Virus Infection - J. Infect. Dis. 161: 567–570.

    Google Scholar 

  35. ter MeulenJ., WittkowskiK.M., KidenyaJ.J., Pö1lathM., DörriesR., FleischerK., DietzK. and ter MeulenV. (1989): Evaluation of Seroepidemiological Associations between HIV-infection, Hepatitis B and other Sexually Transmitted Diseases in African Patients - Eur. J. Immunol. 5: 158–163.

    Google Scholar 

  36. YoungL.S., YaoQ. Y., RooneyCM., SculleyTB., MossDJ, RupaniH., LauxG., BornkammG. W. and RickinsonA.B. (1987): New Type B Isolates of Epstein-Baff Virus from Burkitt's Lymphoma and from Normal Individuals in Endemic Areas - J. Gen. Virol. 68: 2853–2862.

    Google Scholar 

  37. ZimberU., AdldingerH.K., LenoirG.M., VuillaumeM., Knebel-DoeberitzM. Y., LauxG., DesgrangesC, WittmanP., FreeseU.-K., SchneiderU. and BornkammG. W. (1986): Geographical Prevalence of Two Types of Epstein-Barr Virus - Virology 154: 56–66.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Virologie und Immunbiologie, Universität Würzburg, Versbacherstr. 7, 8700, Würzburg, FRG

    S. Essers, A. Schwinn & V. ter Meulen

  2. Deutsches Krebsforschungszentrum, Heidelberg, FRG

    J. ter Meulen

  3. Institut für Medizinische Biometrie, Universität Tübingen, FRG

    H. von Lips & K. Dietz

  4. Department of Microbiologyllmmunology, MMC, Dar-es-Salaam, Tanzania

    F. S. Mhalu & J. Shao

Authors
  1. S. Essers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Schwinn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. ter Meulen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. von Lips
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Dietz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F. S. Mhalu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. Shao
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. V. ter Meulen
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Corresponding author.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Essers, S., Schwinn, A., ter Meulen, J. et al. Seroepidemiological correlations of antibodies to human herpesviruses and human immunodeficiency virus type 1 in African patients. Eur J Epidemiol 7, 658–664 (1991). https://doi.org/10.1007/BF00218678

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00218678

Key words

Search

Navigation