References
Coppola JA (1969) An extragonadal male antifertility agent. Life Sci 8: 43–48
Hirata M, Tanaka A, Omura M, Inoue N (1993) Acute toxicity of dichloropropanols in mice: Comparison between toxicities of two isomers (in Japanese). Jap J Ind Health 35: S400.
Haratake J, Furuta A, Iwasa T, Wakasugi C, Imazu K (1993) Submassive hepatic necrosis induced by dichloropropanol. Liver 13: 123–129.
Kluwe WM, Gupta BN, Lamb JC 4th (1983) The comparative effects of 1,2-dibromo-3-chloropropane (DBCP) and its metabolites, 3-chloro-1,2propaneoxide (epichlorohydrin), 3-chloro-1,2-propanediol (alphachlorohydrin), and oxalic acid, on the urogenital system of male rats. Toxicol Appl Pharmacol 70: 67–86.
Koga M, Inoue N, Imazu K, Yamada N, Shinoki Y (1992) Identification and quantitative analysis of urinary metabolites of dichloropropanols in rats. J UOEH 14: 13–22.
Milby TH and Whorton D (1980) Epidemiological assessment of occupationally related chemically induced sperm count suppression. J Occup Med 22: 77–82.
Mori K, Kaido M, Fujishiro K, Inoue N, Koide O, Hori H, Tanaka I (1991) Dose dependent effects of inhaled ethylene oxide on spermatogenesis in rats. Brit J Ind Med 48: 270–274.
Nakamura T, Nagasawa T, Yu F, Watanabe I, Yamada H (1992) Resolution and some properties of enzymes involved in enantioselective transformation of 1,3-dichloro-2-propanol to (R)-3-chloro-1,2-propanediol by Corynebacterium sp. strain N-1074. J Bacteriol 174: 7613–7619.
Paz GF and Homonnai TZ (1982) A direct effect of alpha-chlorohydrin on rat epididymal spermatozoa. Int J Androl 5: 308–316.
Toth GP, Zenick H, Smith MK (1989) Effects of epichlorohydrin on male and female reproduction in Long-Evans rats. Fundam Appl Toxicol 13: 16–25.
Whorton D, Krauss RM, Marshall S, Milby TH (1977) Infertility in male pesticide workers. Lancet 2: 1259–1261.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Omura, M., Hirata, M., Zhao, M. et al. Comparative testicular toxicities of two isomers of dichloropropanol, 2,3-dichloro-1-propanol, and 1,3-dichloro-2-propanol, and their metabolites alpha-chlorohydrin and epichlorohydrin, and the potent testicular toxicant 1,2-dibromo-3-chloropropane. Bull. Environ. Contam. Toxicol. 55, 1–7 (1995). https://doi.org/10.1007/BF00212381
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00212381