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A new EcoRI polymorphism at the D21S13 locus

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Summary

The D21S13 locus has shown linkage to a gene for familial Alzheimer disease (FAD) on chromosome 21 (St. George-Hyslop et al. 1987). The limited informativeness of probes for this locus have hindered precise mapping of the FAD locus and analysis of nonallelic heterogeneity in FAD (Schellenberg et al. 1988; St. George-Hyslop et al. 1987). We describe a new EcoRI polymorphism at the D21S13 locus that may be useful for the further study of FAD families.

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References

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Authors and Affiliations

  1. Division of Neurology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, University of California, 90048, Los Angeles, CA, USA

    S. -M. Pulst, J. Greenwald & M. Carbone

  2. Division of Medical Genetics, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, University of California, 90048, Los Angeles, CA, USA

    J. R. Korenberg

Authors
  1. S. -M. Pulst
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  2. J. R. Korenberg
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  3. J. Greenwald
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  4. M. Carbone
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Pulst, S.M., Korenberg, J.R., Greenwald, J. et al. A new EcoRI polymorphism at the D21S13 locus. Hum Genet 84, 580 (1990). https://doi.org/10.1007/BF00210815

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  • DOI: https://doi.org/10.1007/BF00210815

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