Skip to main content

Advertisement

Log in

Normal and atopic IgE responses

  • Published:
Springer Seminars in Immunopathology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Andersson U, Andersson J, Lindfors A, Wagern K, Möller G, Heusser CH (1990) Simultaneous production of interleukin 2, interleukin 4 and interferon-γ by activated human blood lymphocytes. Eur J Immunol 20:1591

    Google Scholar 

  2. Armitage RJ, Sato TA, Macduff BM, Clifford KN, Alpert AR, Smith CA, Fanslow WC (1992) Identification of a source of biologically active CD40 ligand. Eur J Immunol 22:2071

    Google Scholar 

  3. Armitage RJ, Fanslow WC, Strockbine L, Sato TA, Clifford KN, Macduff BM, Anderson DM, Gimpel SD, Davis-Smith T, Maliszewski CR, Clark EA, Smith CA, Grabstein KH, Cosman D, Spriggs MK (1992) Molecular and biological characterization of a murine ligand for CD40. Nature 357:80

    Google Scholar 

  4. Carballido JM, Carballido-Perrig N, Terres G, Heusser CH, Blaser K (1992) Bee venom phospholipase A2-specific T cell clones from human allergic and non-allergic individuals: cytokine patterns change in response to the antigen concentration. Eur J Immunol 22:1357

    Google Scholar 

  5. Claassen JL, Levine AD, Buckley RH (1990) Recombinant human IL-4 induces IgE and IgG synthesis by normal and atopic donor mononuclear cells. Similar dose response, time course, requirement for T cells, and effect of pokeweed mitogen. J Immunol d144:2123

    Google Scholar 

  6. Coffman RL, Ohara J, Bond MW, Carty J, Zlotnik A, Paul WE (1986) B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol 136:4538

    Google Scholar 

  7. Cookson WOCM, Young RP, Sandford AJ, Moffatt MF, Shirakawa T, Sharp PA, Faux JA, Julier C, LeSouef PN, Nakumura Y, Lathrop GM, Hopkin JM (1992) Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet 340:381

    Google Scholar 

  8. Cooper K, Kazmierowsky J, Wuepper K, Hanifin J (1983) Immunoregulation in atopic dermatitis: functional analysis of B-T cell interactions and the enumeration of Fc receptor bearing T cells. J Invest Dermatol 80:139

    Google Scholar 

  9. Defrance T, Vanbervliet B, Brière F, Durand I, Rousset F, Banchereau J (1992) Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J Exp Med 175:671

    Google Scholar 

  10. Esser C, Radbruch A (1990) Immunoglobulin class switching: molecular and cellular analysis. Annu Rev Immunol 8:717

    Google Scholar 

  11. Finkelman FD, Holmes J, Katona IM, Urban JF, Beckmann MP, Park LS, Schooley KA, Coffman RL, Mosmann TR, Paul WE (1990) Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 8:303

    Google Scholar 

  12. Fiser PM, Buckley RH (1979) Human IgE biosynthesis in vitro: studies with atopic and normal blood mononuclear cells and subpopulations. J Immunol 123:1788

    Google Scholar 

  13. Gascan H, Gauchat JF, Roncarolo MG, Yssel H, Spits H, deVries JE (1991) Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones. J Exp Med 173:747

    Google Scholar 

  14. Gauchat JF, Aversa G, Gascan H, deVries JE (1992) Modulation of IL-4 induced germline ɛ RNA synthesis in human B cells by tumor necrosis factor-α, anti-CD40 monoclonal antibodies or transforming growth factor-β correlates with levels of IgE production. Int Immunol 4:397

    Google Scholar 

  15. Hellman L, Josephson S, Jernberg H, Nilsson K, Pettersson U (1988) Immunoglobulin synthesis in the human myeloma cell line U-266: expression of two immunoglobulin heavy chain isotypes (ɛ and α) after long-term cultivation in vitro. Eur J Immunol 18:905

    Google Scholar 

  16. Hibi T, Dosch HM (1986) Limiting dilution analysis of the B cell compartment in human bone marrow. Eur J Immunol 16:139

    Google Scholar 

  17. Janossy G, Gomez de la Concha E, Luquetti A, Snajdr MJ, Waxdal MJ, Platts-Mills TAE (1977) T-cell regulation of immunoglobulin synthesis and proliferation in pokeweed (Pa-1)-stimulated human lymphocyte cultures. Scand J Immunol 6:109

    Google Scholar 

  18. Kapsenberg ML, Wierenga EA, Bos JD, Jansen HM (1991) Functional subsets of allergenreactive human CD4+ T cells. Immunol Today 12:392

    Google Scholar 

  19. King CL, Poindexter RW, Ragunathan J, Fleisher TA, Ottesen EA, Nutman TB (1991) Frequency analysis of IgE-secreting B lymphocytes in persons with normal or elevated serum IgE levels. J Immunol 146:1478

    Google Scholar 

  20. Kühn R, Rajewsky K, Müller W (1991) Generation and analysis of interleukin-4 deficient mice. Science 254:707

    Google Scholar 

  21. Lebman DA, Coffman RL (1988) Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures. J Exp Med 168:853

    Google Scholar 

  22. Lundgren M, Persson U, Larsson P, Magnusson C, Smith CIE, Hammerström L, Severinson E (1989) Interleukin 4 induces synthesis of IgE and IgG4 in human B cells. Eur J Immunol 19:1311

    Google Scholar 

  23. Maggi E, DelPrete GF, Tiri A, Macchia D, Parronchi P, Ricci M, Romagnani S (1988) T cell clones providing helper function for IgE synthesis release soluble factor(s) that induce IgE production in human B cells: possible role for interleukin 4 (IL-4). Clin Exp Immunol 73:57

    Google Scholar 

  24. Mills FC, Thyphronitis G, Finkelman FD, Max EE (1992) Ig μ-ɛ isotype switch in IL-4-treated human B lymphoblastoid cells: evidence for a sequential switch. J Immunol 149:1075

    Google Scholar 

  25. O'Hehir RE, Garman RD, Greenstein JL, Lamb JR (1991) The specificity and regulation of T-cell responsiveness to allergens. Annu Rev Immunol 9:67

    Google Scholar 

  26. Pène J, Roussel F, Brière F, Chrétien I, Bonnefoy JY, Spits H, Yokota T, Arai N, Arai KI, Banchereau J, deVries JE (1988) IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons γ and α and prostaglandin E2. Proc Natl Acad Sci USA 85:6880

    Google Scholar 

  27. Röcken M, Saurat JH, Hauser C (1992) A common precursor for CD4+ T cells producing IL-2 or IL-4. J Immunol 148:1031

    Google Scholar 

  28. Romagnani S (1990) Regulation and deregulation of human IgE synthesis. Immunol Today 11:316

    Google Scholar 

  29. Rousset F, Robert J, Andary M, Bonnin JP, Souillet G, Chrétien I, Brière F, Pène J, deVries JE (1991) Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis. J Allergy Clin Immunol 87:58

    Google Scholar 

  30. Rousset F, Garcia E, Banchereau J (1991) Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J Exp Med 173:705

    Google Scholar 

  31. Shapira SK, Vercelli D, Jabara HH, Fu SM, Geha RS (1992) Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen. J Exp Med 175:289

    Google Scholar 

  32. Spiegelberg HL (1990) The role of interleukin-4 in IgE and IgG subclass formation. Springer Semin Immunopathol 12:365

    Google Scholar 

  33. Tepper RI, Pattengale PK, Leder P (1989) Murine interleukin-4 displays potent anti-tumor activity in vivo. Cell 57:503

    Google Scholar 

  34. Tepper RI, Levinson DA, Stanger BZ, Campos-Torres J, Abbas AK, Leder P (1990) IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62:457

    Google Scholar 

  35. Tucci A, Mouzaki A, James H, Bonnefoy JY, Zubler RH (1991) Are cord blood B cells functionally mature? Clin Exp Immunol 84:389

    Google Scholar 

  36. Tucci A, James H, Chicheportiche R, Bonnefoy J-Y, Dayer J-M, Zubler RH (1992) Effects of eleven cytokines and of IL-1 and tumor necrosis factor inhibitors in a human B cell assay. J Immunol 148:2778

    Google Scholar 

  37. vanVlasselaer P, Punnonen J, deVries JE (1992) Transforming growth factor-β directs IgA switching in human B cells. J Immunol 148:2062

    Google Scholar 

  38. Vercelli D, Jabara HU, Arai KI, Geha R (1989) Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med 169:1295

    Google Scholar 

  39. Vernino L, McAnally LM, Ramberg J, Lipsky PE (1992) Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated with anti-CD3-activated T cells. J Immunol 148:404

    Google Scholar 

  40. Vollenweider S, Saurat JH, Röcken M, Hauser C (1991) Evidence suggesting involvemenl of interleukin-4 (IL-4) produclion in sponlaneous in vitro IgE synthesis in patients with atopic dermatitis. J Allergy Clin Immunol 87:1088

    Google Scholar 

  41. Wen L, Hanvanich M, Werner-Favre C, Brouwers N, Perrin LH, Zubler RH (1987) Limiting dilution assay for human B cells based on their activation by mutant EL4 thymoma cells: total and anti-malaria responder B cell frequencies. Eur J Immunol 17:887

    Google Scholar 

  42. Yoshida M, Matsuoka M, Usuda S, Mori A, Ishizaka K, Sakano H (1990) Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from μ to ɛ via gl. Proc Natl Acad Sci USA 87:7829

    Google Scholar 

  43. Zhang X, Werner-Favre C, Tang H, Brouwers N, Bonnefoy JY, Zubler RH (1991) IL-4-dependent IgE switch in membrane IgA-positive human B cells. J Immunol 147:3001

    Google Scholar 

  44. Zhang X, Polla B, Hauser C, Zubler RH (1992) T cells from atopic individuals produce IgE-producing activity incompletely blocked by anti-interleukin-4 antibody. Eur J Immunol 22:829

    Google Scholar 

  45. Zubler RH, Werner-Favre C, Wen L, Sekita KI, Straub C (1987) Theoretical and practical aspects of B-cell activation: murine and human systems. Immunol Rev 99:281

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zubler, R.H., Zhang, X., Tucci, A. et al. Normal and atopic IgE responses. Springer Semin Immunopathol 15, 29–36 (1993). https://doi.org/10.1007/BF00204624

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00204624

Keywords

Navigation