Abstract
Squamous cell carcinoma (SCC) of the renal pelvis is an uncommon tumour that has occasionally been associated with horseshoe kidney. The verrucous form of well-differentiated SCC has not been described previously at this site. We describe such a tumour in a 41-year-old man, who presented with gross haematuria and recurrent pyelonephritis caused by staghorn calculi within a horseshoe kidney. Histology showed extensive keratinising squamous metaplasia of the pelvic urothelium with an area of verrucous acanthosis and underlying invasion of the pelvic smooth muscle by broad tongues of squamous epithelium without atypia. Local lymph nodes were not involved by tumour. Immunohistochemistry and polymerase chain reaction revealed no evidence of human papillomavirus infection. The literature regarding verrucous carcinoma of the urothelial tract is reviewed.
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References
Ackerman LV (1948) Verrucous carcinoma of the oral cavity. Surgery 23:670
Batta AG, Engen DE, Reiman HM, Winkleman RK (1990) Intravesical condyloma acuminatum with progression to verrucous carcinoma. Urology 36:457–464
Boileau M, Hui KKS, Cowan DF (1986) Invasive verrucous carcinoma of urinary bladder treated by irradiation. Urology 27:56–59
Cotran RS, Kumar V, Robbins SL (1989) Pathologic basis of disease, 4th edn. Saunders, Philadelphia
Cupp MR, Malek RS, Goellner JR, Smith TF, Espy MJ (1995) The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis. J Urol 154:1024–1029
El-Bolkainy MN, Mokhtar NM, Ghoneim MA, Hussein MH (1981) The impact of schistosomiasis on the pathology of bladder carcinoma. Cancer 48:2643–2648
Ellsworth PI, Schned AR, Heaney JA, Snyder PM (1995) Surgical treatment of verrucous carcinoma of the bladder unassociated with bilharzial cystitis: case report and literature review. J Urol 153:411–414
Fukunaga M, Yokoi K, Miyazawa Y, Harada T, Ushigome S (1994) Penile verrucous carcinoma with anaplastic transformation following radiotherapy. A case report with human papillomvirus typing and flow cytometric DNA studies. Am J Surg Pathol 18:501–505
Holck S, Jorgenson L (1983) Verrucous carcinoma of urinary bladder. Urology 22:435–437
Horner SA, Fisher HAG, Barada JH, Eastman AY, Migliozzi J, Ross JS (1991) Verrucous carcinoma of the bladder. J Urol 145:1261–1263
Masih AS, Stoler MH, Farrow GM, Wooldridge TN, Johansson SL (1992) Penile verrucous carcinoma: a clinicopathological, human papillomavirus typing and flow cytometric analysis. Mod Pathol 5:48–55
Masih AS, Stoler MH, Farrow GM, Johansson SL (1993) Human paillomavirus in penile squamous cell lesions. A comparison of an isotopic RNA and two commercial nonisotopic DNA in situ hybridization methods. Arch Pathol Lab Med 117:302–307
Nagar RC, Sanwad BL (1989) Squamous cell carcinoma in a horseshoe kidney. J Indian Med Assoc 87:14–16
Peterson RO (1992) Urologic pathology, 2nd edn. Lippincott, Philadelphia
Pierangeli T, Grifoni R, Marchi P, Montironi R, Stefano S (1989) Verrucous carcinoma in situ of the bladder, not associated with urinary schistosomiasis. Int Urol Nephrol 21:597–602
Pilotti S, Donghi R, D'Amato L, Giarola M, Longoni A, Della Torre G, DePalo G, Pierotti MA, Rilke F (1993) HPV detection and p53 alteration in squamous cell verrucous malignancies of the lower genital tract. Diagn Mol Pathol 2:248–256
Reed HM, Robinson ND (1984) Horseshoe kidney with simultaneous occurrence of calculi, transitional cell and squamous cell carcinoma. Urology 23:62–64
Regezi JA, Zarbo RJ, Regev E, Pisanty S, Silverman S, Gazit D (1995) p53 protein expression in sequential biopsies of oral dysplasias and in situ carcinomas. J Oral Pathol Med 24:18–22
Schwartz RA, Nychay SG, Lyons M, Sciales CW, Lambert WC (1991) Buschke-Lowenstein tumor: verrucous carcinoma of the anogenitalia. Cutis 47:263–266
Walther M, O'Brien DP III, Birch HW (1986) Condyloma acuminata and verrucous carcinoma of the bladder: case report and literature review. J Urol 135:362–365
Weschler Z (1983) Squamous cell carcinoma of the renal pelvis as a late complication of hepatic irradiation. A case report. J Surg Oncol 22:84
Wyatt JK, Craig I (1980) Verrucous carcinoma of the urinary bladder. Urology 16:97–99
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Sheaff, M., Baithun, S., Fociani, P. et al. Verrucous carcinoma of the renal pelvis: case presentation and review of the literature. Vichows Archiv A Pathol Anat 428, 375–379 (1996). https://doi.org/10.1007/BF00202204
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DOI: https://doi.org/10.1007/BF00202204