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Normalization of defective monocyte chemotaxis during chemotherapy in patients with small cell anaplastic carcinoma of the lung

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Summary

Monocyte chemotactic responsiveness (MCR) in 14 patients with small cell anaplastic bronchogenic carcinoma was depressed before treatment compared with the MCR in 28 normal controls (P=0.00004). MCR was subsequently monitored during combination chemotherapy and after 6 months the MCR had become normalized compared with pretreatment values (P=0.00006).

In addition, chemotactic factor inhibitor (CFI) activity in plasma was measured before treatment and after 6 months. When incubated with plasma before treatment casein had 62% of normal activity and when incubated with plasma after chemotherapy, 81% of normal activity (P=0.0009). CFI activity decreased by greater amounts in patients in complete remission than in patients in partial remission or in non-responders (P=0.01). This study supports the concept that cancer patients have depressed monocyte function. Chemotherapy seems to enhance monocyte chemotaxis in vitro and to decrease CFI activity in plasma.

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Authors and Affiliations

  1. Medical Department C, Bispebjerg Hospital, DK-2300, Copenhagen

    H. Nielsen

  2. Infection Immunity Group and Tuberculosis Department, Statens Seruminstitut, Amager Boulevard 80, DK-2300, Copenhagen S

    J. Bennedsen

  3. Department of Oncology, Herlev Hospital, DK-2300, Copenhagen, Denmark

    P. Dombernowsky

Authors
  1. H. Nielsen
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  2. J. Bennedsen
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  3. P. Dombernowsky
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Nielsen, H., Bennedsen, J. & Dombernowsky, P. Normalization of defective monocyte chemotaxis during chemotherapy in patients with small cell anaplastic carcinoma of the lung. Cancer Immunol Immunother 14, 13–15 (1982). https://doi.org/10.1007/BF00199426

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  • DOI: https://doi.org/10.1007/BF00199426

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