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Immunity to the thyroid-stimulating hormone receptor

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References

  1. Adams DD, Purves HD (1956) Abnormal responses in the assay of thyrotropin. Proc Univ Otago Med Sch 34:11

    Google Scholar 

  2. Allanic H, Fauchet R, Orgiazzi J, Madec AM, Genetet B, Lorcy Y, le Guerrier AM, Delambre C, Derennes V (1990) Antithyroid drugs and Graves' disease: a prospective randomised evaluation of the efficacy of treatment duration. J Clin Endocrinol Metab 70:675

    Google Scholar 

  3. Atassi Z, Manshouri T, Sakata S (1991) Localisation and synthesis of the hormone binding regions of the human thyrotropin receptor. Proc Natl Acad Sci USA 88:3613

    Google Scholar 

  4. Bech K, Bliddal H, Siersbaek-Nielsen K, Friis T (1982) Production of non-stimulatory immunoglobulins that inhibit TSH binding in Graves' disease after radioiodine administration. Clin Endocrinol 17:395

    Google Scholar 

  5. Brabant G, Maenhaut C, Kohrle J, Scheumann G, Dralle H, Hoang-Vu C, Hesch RD, von zur Muhlen A, Vassart G, Dumont JE (1991) Human thyrotropin receptor gene: expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation. Mol Cell Endocrinol 82:R7

    Google Scholar 

  6. Brown RS, Keating P, Mitchell E (1990) Maternal thyroid-blocking immunoglobulins in congenital hypothyroidism. J Clin Endocrinol Metab 70:1341

    Google Scholar 

  7. Cho BY, Oh SK, Shong YK, Kim SE, Yoo HY, Lee HK, Koh CS, Min HK (1990) Changes in thyrotropin receptor antibody after subtotal thyroidectomy in Graves' disease: comparison with the degree of lymphocyte infiltration in the thyroid. Autoimmunity 8:143

    Google Scholar 

  8. Edau G, Massart C, Hody B, Poirier JY, le Reun M, Hespel JP, Leclech G, Simon M (1989) Optimum duration of antithyroid drug treatment determined by assay of thyroid stimulating antibody in patients with Graves' disease. Br Med J 298:358

    Google Scholar 

  9. Endo T, Ohmori M, Ikede M, Onaya T (1991) Thyroid stimulating activity of rabbit antibodies toward the human thyrotropin receptor peptide. Biochem Biophys Res Commun 177:145

    Google Scholar 

  10. Endo T, Ohmori M, Ikede M, Onaya T (1991) Rabbit antibodies toward extracellular loops of the membrane spanning regions of human thyrotropin receptor possess thyroid stimulating activities. Biochem Biophys Res Commun 181:1035

    Google Scholar 

  11. Filetti S, Foti D, Costante G, Rapoport B (1991) Recombinant human thyrotropin (TSH) receptor in a radioreceptor assay for the measurement of TSH receptor autoantibodies. J Clin Endocrinol Metab 72:1096

    Google Scholar 

  12. Frazier A, Robbins L, Stork P, Sprengel R, Segaloff D, Cone R (1990) Isolation of TSH and LH/hCG receptors cDNAs from human thyroid: regulation by tissue-specific splicing. Mol Endocrinol 4:1264

    Google Scholar 

  13. Furmaniak J, Davenport S, Nakajima Y, Kaiser U, Muller-Gartner HW, Buckmann FW, Pegg C, Rees Smith B (1988) Analysis of TSH receptors and microsomal antigen in different human thyroid tissue specimens. Clin Endocrinol 28:589

    Google Scholar 

  14. Gross B, Misrahi M, Sar S, Milgrom E (1991) Composite structure of the human thyrotropin receptor gene. Biochem Biophys Res Commun 177:679

    Google Scholar 

  15. Hashim FA, Creagh FM, El Hawrani A, Parkes AB, Buckland PR, Rees Smith B (1986) Characterization of TSH antagonist activity in the serum of patients with thyroid disease. Clin Endocrinol 25:275

    Google Scholar 

  16. Hashizume K, Ichikawa K, Sakurai A, Suzuki S, Takeda T, Kobayashi M, Miyamoto T, Arai M, Nagasawa T (1991) Administration of thyroxine in treated Graves' disease. Effects on the level of antibodies to thyroid-stimulating hormone receptors and on the risk of recurrence of hyperthyroidism. N Engl J Med 324:947

    Google Scholar 

  17. Hexham JM, Persson MAA, Pegg C, Burton DR, Furmaniak J, Rees Smith B (1991) Cloning and expression of a human thyroglobulin autoantibody. Autoimmunity 11:69

    Google Scholar 

  18. Huse WO, Sastry L, Iverson SA, Kang AS, Alting-Mees M, Burton DR, Benkovic SJ, Lerner RA (1989) Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 246:1275

    Google Scholar 

  19. Kielczynski W, Harrison LC, Leedman PJ (1991) Direct evidence that ganglioside is an integral component of the thyrotropin receptor. Proc Natl Acad Sci USA 88:1991

    Google Scholar 

  20. Knight J, Laing P, Knight A, Adams D, Ling N (1986) Thyroid stimulating autoantibodies usually contain only lambda chains: evidence for the “forbidden clone” theory. J Clin Endocrinol Metab 62:342

    Google Scholar 

  21. Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495

    CAS  PubMed  Google Scholar 

  22. Konishi J, Iida Y, Endo K, Misaki T, Nohara Y, Matsuura N, Mori T, Torizuka K (1983) Inhibition of thyrotropin-induced adenosine 3′-5′-monophosphate increase by immunoglobulins from patients with primary myxedema. J Clin Endocrinol Metab 57:544

    Google Scholar 

  23. Kraiem Z, Lahat N, Glaser B, Baron E, Sadeh O, Sheinfeld M (1987) Thyrotropin receptor-blocking antibodies: incidence, characterisation and in vitro synthesis. Clin Endocrinol 27:409

    Google Scholar 

  24. Lefkowitz RJ, Caron MG (1988) Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins. J Biol Chem 263:4993

    Google Scholar 

  25. Libert F, Lefort A, Gerard C, Parmentier M, Perret J, Ludgate M, Dumont JE, Vassart G (1989) Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem Biophys Res Commun 165:1250

    Google Scholar 

  26. Ludgate M, Perret J, Parmentier M, Gerard C, Libert F, Dumont JE, Vassart G (1990) Use of the recombinant human thyrotropin receptor (TSH-R) expressed in mammalian cell lines to assay TSH-R autoantibodies. Mol Cell Endocrinol 73:R13

    Google Scholar 

  27. Ludgate M, Perret J, Libert F (1991) Assay of thyrotropin receptor (TSH-R) autoantibodies using recombinant TSH-R expressed in mammalian cells. Ann Endocrinol (Paris) 52:149

    Google Scholar 

  28. Macchia E, Concetti R, Carone G, Borgou F, Fenzi GF, Pinchera A (1988) Demonstration of blocking immunoglobulin G, having a heterogeneous behaviour, in sera of patients with Graves' disease: possible coexistence of different autoantibodies directed to the TSH receptor. Clin Endocrinol 28:147

    Google Scholar 

  29. Matsuura N, Konishi J, Fujieda K, Kasagi K, Iida Y, Hagisawa M, Fujimoto S, Fukushi M, Takasugi N (1988) TSH-receptor antibodies in mothers with Graves' disease and outcome in their offspring. Lancet II:14

    Google Scholar 

  30. McKenzie JM, Zakarija M (1989) The clinical use of thyrotropin receptor antibody measurements. J Clin Endocrinol Metab 69:1093

    Google Scholar 

  31. Misrahi M, Loosfelt H, Atger M, Sar S, Goiochou-Mantel A, Milgrom E (1990) Cloning, sequencing and expression of human TSH receptor. Biochem Biophys Res Commun 166:394

    Google Scholar 

  32. Nagayama Y, Kaufman KD, Seto P, Rapaport B (1989) Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun 165:1184

    Google Scholar 

  33. Nagayama Y, Russo D, Chazenbalk GD, Wadsworth HL, Rapoport B (1990) Extracellular domain chimeras of the TSH and LH/CG receptors reveal the mid region (aminoacids 171–260) to play a vital role in high affinity TSH binding. Biochem Biophys Res Commun 173:1150

    Google Scholar 

  34. Nagayama Y, Wadsworth H, Chazenbalk G, Russo D, Seti P, Rapoport B (1991) TSH-LH/CG receptor extracellular domain chimeras as probes for TSH receptor function. Proc Natl Acad Sci USA 88:902

    Google Scholar 

  35. Nagayama Y, Russo D, Wadsworth HL, Chazenbalk GD, Rapoport B (1991) Eleven amino acids (lys-201-lys-211) and 9 amino acids (gly-222 to leu-230) in the human thyrotropin receptor are involved in ligand binding. J Biol Chem 266:14926

    Google Scholar 

  36. Nagayama Y, Wadsworth HL, Russo D, Chazenbalk GD, Rapoport B (1991) Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-leutropin/chorionic gonadotropin receptors. J Clin Invest 88:336

    Google Scholar 

  37. Nordmeyer JP, Hashim FA, Shafeh T, Eickenbusch W, Rees Smith B (1988) TSH receptor antibodies in autoimmune thyroiditis. J Clin Lab Immunol 26:21

    Google Scholar 

  38. Ohmori M, Endo T, Onaya T (1991) Development of chicken antibodies toward the human thyrotropin receptor peptides and their bioactivities. Biochem Biophys Res Commun 174:399

    Google Scholar 

  39. Ohta K, Endo T, Onaya T (1990) The mRNA levels of thyrotropin receptor, thyroglobulin and thyroid peroxidase in neoplastic human thyroid tissues. Biochem Biophys Res Commun 174:1148

    Google Scholar 

  40. Parmentier M, Libert F, Maenhart C, Lefort A, Gerhard C, Perret J, Van Sande J, Dumont JE, Vassart G (1989) Molecular cloning of the thyrotropin receptor. Science 246:1620

    Google Scholar 

  41. Portolano S, Seto P, Chazenbalk GD, Nagayama Y, McLachlan SM, Rapoport B (1991) A human Fab fragment specific for thyroid peroxidase generated by cloning thyroid lymphocyte-derived immunoglobulin genes in a bacteriophage lambda library. Biochem Biophys Res Commun 179:372

    Google Scholar 

  42. Rees Smith B, McLachlan SM, Furmaniak J (1988) Autoantibodies to the thyrotropin receptor. Endocr Rev 9:106

    Google Scholar 

  43. Rehfuss LR, Robbins LS, Cone RD (1992) Thyrotropin receptor messenger ribonucleic acid is expressed in most brown and white adipose tissues in the guinea pig. Endocrinology 130:1857

    Google Scholar 

  44. Russo D, Chazenbalk GD, Nagayama Y, Wadsworth HL, Seto P, Rapoport B (1991) A new structural model for the thyrotropin receptor as determined by covalent cross-linking of thyrotropin to the recombinant receptor in intact cells: evidence for a single polypeptide chain. Mol Endocrinol 5:1607

    Google Scholar 

  45. Southgate K, Creagh FM, Teece M, Kingswood C, Rees Smith B (1984) A receptor assay for the measurement of TSH receptor antibodies in unextracted serum. Clin Endocrinol 1984, 20:539

    Google Scholar 

  46. Tahara K, Ban T, Minegishi T, Kohn LD (1991) Immunoglobulins from Graves' patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients. Biochem Biophys Res Commun 179:70

    Google Scholar 

  47. Takasu N, Yamada T, Sato A, Nakagawa M, Komiya I, Nagasawa Y, Asawa T (1990) Graves' disease following hypothyroidism due to Hashimoto's disease: studies of eight cases. Clin Endocrinol 33:687

    Google Scholar 

  48. Tamai H, Kasagi K, Takaichi Y, Takamatsu Y, Komaki K, Matsubayashi S, Konishi J, Kuma K, Kumagi IF, Nagataki S (1989) Development of spontaneous hypothyroidism in patients with Graves' disease treated with antithyroidal drugs: clinical, immunological and histological findings in 26 patients. J Clin Endocrinol Metab 69:49

    Google Scholar 

  49. Tamaki H, Amino N, Iwatani Y, Tachi J, Kimura M, Mitsuda N, Ichihara K, Tanizawa O, Miyai K (1989) Evaluation of TSH receptor antibody by “natural in vivo human assay” in neonates born to mothers with Graves' disease. Clin Endocrinol 30:493

    Google Scholar 

  50. Tamaki H, Amino N, Aozasa M, Mori M, Tanizawa O, Miyai K (1987) Serial changes in thyroid-stimulating antibody and thyrotropin binding inhibitor immunoglobulin at the time of postpartum occurrence of thyrotoxicosis in Graves' disease. J Clin Endocrinol Metab 65:324

    Google Scholar 

  51. Wadsworth HL, Chazenbalk GD, Nagayama Y, Russo D, Rapoport B (1990) An insertion in the human thyrotropin receptor critical for high affinity hormone binding. Science 249:1423

    Google Scholar 

  52. Weetman AP, Byfield PGM, Blech C, Reimer CB (1990) IgG heavy-chain subclass restriction of thyrotropin binding inhibitory immunoglobulins in Graves' disease. Eur J Clin Invest 20:406

    Google Scholar 

  53. Weetman AP, Yateman ME, Ealey PA, Black GM, Reimer CB, Williams RC Jr, Shine B, Marshall NJ (1990) Thyroid stimulating antibody activity between different immunoglobulin G subclasses. J Clin Invest 86:723

    Google Scholar 

  54. Williams RC, Marshall NJ, Kilpatric K, Montano J, Brickell PM, Goodall M, Ealey PA, Shine B, Weetman AP, Craig RK (1988) Kappa/lambda immunoglobulin distribution in Graves' thyroid stimulating antibody. J Clin Invest 82:1306

    Google Scholar 

  55. Wilson R, Fraser WD, McKillop JH, Thomson JA (1989) The prognostic value of TSH receptor binding and thyroid stimulating antibodies following antithyroid drug treatment of Graves's disease. Acta Endocrinol 121:666

    Google Scholar 

  56. Wilson R, McKillop JH, Jenkins C, Thomson JA (1991) In vivo and in vitro studies into the immunological changes following iodine 131 therapy for Graves' disease. Eur J Nucl Med 18:265

    Google Scholar 

  57. Zakarija M, McKenzie JM, Hoffman WH (1986) Prediction and therapy of intrauterine and late onset neonatal hyperthyroidism. J Clin Endocrinol Metab 62:368

    Google Scholar 

  58. Zakarija M, McKenzie JM, Eidson MS (1990) Transient neonatal hypothyroidism: characterisation of maternal antibodies to the thyrotropin receptor. J Clin Endocrinol Metab 70:1239

    Google Scholar 

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Furmaniak, J., Smith, B.R. Immunity to the thyroid-stimulating hormone receptor. Springer Semin Immunopathol 14, 309–321 (1993). https://doi.org/10.1007/BF00195980

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