Skip to main content
Log in

Excessive iron storage in a patient with Wilson's disease

  • Case Report
  • Published:
Journal of Molecular Medicine Aims and scope Submit manuscript

Abstract

We report on an otherwise healthy female, mother of two children, with severe decompensated liver cirrhosis due to an iron overload and Wilson's disease. The patient was considered heterozygote for hemochromatosis on the basis of the autosomal recessive inheritance for hemochromatosis, the frequency of the hemochromatosis gene, and the laboratory parameters defining her iron overload. The case is interesting because of the coincidence of Wilson's disease and excessive iron storage.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Brewer GJ, Yuzbasiyan-Gurkan V (1992) Wilson disease. Medicine 71:139–164

    Article  CAS  PubMed  Google Scholar 

  2. Gollan J (1983) Diagnosis of hemochromatosis. Gastroenterology 84:418–421

    CAS  PubMed  Google Scholar 

  3. Conte D, Piperno A, Mandeli C, Fargion S, Cesana M, Brunelli L, Ferrario L, Velio P, Zamarella MG, Tiribelli C, Fiorelli G, Bianchi PA (1986) Clinical, biochemical and histological features of primary hemochromatosis: a report of 67 cases. Liver 6:310–315

    Article  CAS  PubMed  Google Scholar 

  4. Edwards CQ, Griffen LM, Goldgar D, Drummond C, Skolnick MH, Kushner JP (1988) Prevalence of hemochromatosis among 11065 presumably healthy blood donors. N Engl J Med 318:1355–1362

    Article  CAS  PubMed  Google Scholar 

  5. Muench KH (1989) Hemochromatosis and infection: alcohol and iron, oysters and sepsis. Am J Med 87:40–43

    Article  Google Scholar 

  6. Niederau C, Stremmel W, Strohmeyer G (1990) Früherkennung der hereditdren Hdmochromatose und des Morbus Wilson. Z Gastroenterol Verhandlungsband 26:82–87

    Google Scholar 

  7. Propper R, Nathan D (1982) Clinical removal of iron. Annu Rev Med 33:509–519

    Article  CAS  PubMed  Google Scholar 

  8. Stremmel W (1992) Pathogenese des Morbus Wilson. Z Gastroenterol 30:199–201

    CAS  PubMed  Google Scholar 

  9. Strickland GT, Frommer D, Len ML, Pollard R, Sherlock S, Cumings JN (1973) Wilson's disease in the United Kingdom and Taiwan. Q J Med 167:619–638

    Google Scholar 

  10. Stremmel W (1991) Wertigkeit des Gewebeeisenindex bei der Differentialdiagnose zwischen primdrer Hdmochroma tose und alkoholisch bedingter Lebererkrankung. Z Gastroenterol 29:621

    CAS  PubMed  Google Scholar 

  11. Summers KM, Halliday JW, Powell LW (1990) Identification of homozygous hemochromatosis subjects by measurement of hepatic iron index. Hepatology 12:20–25

    Article  CAS  PubMed  Google Scholar 

  12. Uzman LL (1985) Histochemical localization of copper with rubeanic acid. Lab Invest 5:299–305

    Google Scholar 

  13. Yarze JC, Martin P, Munoz SJ (1992) Wilson's disease: Current Status. Am J Med 92:643–654

    Article  CAS  PubMed  Google Scholar 

  14. Valberg LS, Lloyd DA, Ghent CN, Flanagan PR, Sinclair NR, Stiller CR, Chamberlain MJ (1980) Clinical and biochemical expression of the genetic abnormality in idiopathic hemochromatosis. Gastroenterology 79:884–892

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Correspondence to: D. Haussinger

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hafkemeyer, P., Schupp, M., Storch, M. et al. Excessive iron storage in a patient with Wilson's disease. Clin Investig 72, 134–136 (1994). https://doi.org/10.1007/BF00184590

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00184590

Key words

Navigation