Abstract
The case of a 70-year-old patient with an epithelial mesothelioma is presented. The patient suffered from dyspnea due to a right-sided recurrent hemorrhagic effusion. Cytological analysis of the effusion revealed marked lymphocytosis and tumor cells, some of them multinucleated with prominent nucleoli. Open lung biopsy revealed nodular thickening of the diaphragmatic, visceral, and parietal pleura; histological examination of biopsies detected intravascular growth of tumor cells. Immunocytochemical characterization of cultured tumor cells and the biopsy specimens showed positive staining to vimentin and cytokeratin, but negative reaction with antibodies against epithelial membrane associated antigen, leukocyte common antigen, van Willebrand factor, and neurofilament. Hence, the tumor was classified as malignant mesothelioma. In vitro, interferon-α2 produced a dose-dependent inhibition of proliferation in the cultured mesothelioma cells. Two weeks after initiation of interferon-α2 treatment the patient improved and the pleural effusion vanished.
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References
Adams VI, Unni KK, Muhm JR, Jett JR, Ilstrup DM, Bernatz PE (1986) Diffuse malignant mesothelioma of pleura: diagnosis and survival in 92 cases. Cancer 58:1540–1551
Boutin C, Viallat JR, Van Zandwijk N, Douillard JT, Paillard JC, Guerin JC, Mignot P, Migueres J, Varlet F, Jehan A, Deleoulle E, Brandely M (1991) Activity of intra-pleural recombinant gamma-interferon in malignant mesothelioma. Cancer 67:2033–2037
Bowman RV, Manning LS, Davis MR, Robinson BW (1991) Chemosensitivity and cytokine-sensitivity of malignant mesothelioma. Cancer Chemother Pharmacol 28:420–426
Hand AM, Husgafvel-Pursiainen K, Tammilehto L, Mattson K, Linnainmaa K (1991) Malignant mesothelioma: the antiproliferative effect of cytokine combinations on three human mesothelioma cell lines. Cancer Lett 58:205–210
Herberman RB, Djeu JY, Ortaldo JR, Holden HT, West WH, Bonnard GD (1978) Role of interferon in augmentation of natural and antibody-dependant cell-mediated cytotoxicity. Cancer Treat Rep 62:1893–1903
Kittle CF (1987) Mesothelioma diagnosis and management, Year Book Medical Publishers, Chicago
Liu CC, Joag SV, Kwon BS, Young JDE (1990) Induction of perforin and serine esterases in a murine cytotoxic T lymphocte clone. J Immunol 144:1192–1201
Manning LS, Bowman RV, Darby SB, Robinson BWS (1989) Lysis of human malignant mesothelioma cells by natural killer (NK) and lymphokine-activated killer (LAK) cells. Am Rev Respir Dis 139:1369–1374
Pasternack MS, Eisen HN (1985) A novel serine esterase expressed by cytotoxic T lymphocytes. Nature 314:743–745
Pisani RJ, Colby TV, Williams DE (1988) Malignant mesothelioma of the pleura. Mayo Clin Proc 63:1234–1244
Sklarin NT, Chahinian AP, Feuer EJ, Lahman LA, Szajer L, Holland JF (1988) Augmentation of activity of cis-Di-amminedichloroplatinum (II) and mitomycin C by interferon in human malignant mesothelioma xenografts in nude mice. Cancer Res 84:64–67
Solomons K, Polakow R, Marchand P (1985) Diffuse malignant mesothelioma presented as a bilateral malignant lymphangitis. Thorax 40:682–683
Von Hoff DD, Metch B, Lucas JG, Balcerzak SP, Grunberg SM, Rivkin SE (1990) Phase 11 evaluation of recombinant interferon-beta (IFN-beta Set) in patients with diffuse mesothelioma: a Southwest Group Oncology Study. J Interferon Res 10:531–534
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Correspondence to: V Sexl
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Sexl, V., Wagner, L., Wiesholzer, M. et al. Treatment of a patient with malignant mesothelioma with interferon-α2 based on in vitro sensitivity tests. Clin Investig 72, 317–320 (1994). https://doi.org/10.1007/BF00180050
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DOI: https://doi.org/10.1007/BF00180050