Abstract
An integrated approach to existing methods of extracting biodistribution data, pharmacokinetics and radiation absorbed dose estimates from serial scintigraphic images is described. This approach employs a single computer-generated user interface to reformat planar scans into a standard file type, align conjugate (anterior and posterior) images, draw regions of interest (ROIs) over selected organs and lesions and generate count data for anterior and posterior views and calculated geometric means. Using standard correction methods, the fraction injected activity is obtained for all ROIs and total body. This methodology has been applied to the analysis of indium-III-labelled breast-cancer-directed antibodies and technetium-90m-labelled CEA-specific antibody fragments in non-small-cell lung cancer. It is anticipated that this approach will be useful for evaluating the dosimetry of other radiolabelled monoclonal antibodies, as well as other radiopharmaceuticals.
This is a preview of subscription content, log in via an institution to check access.
References
Barrett H, Foster D (1990) CONSAM version 30. Resource facility for kinetic analysis. SAAM — originally developed at NIH by Mones Berman and Marjory F. Weiss, Center for Bioengineering, University of Washington, Seattle, Washington.
Becker RA, Chambers JM, Wilks AR (1988) The new S language. Wadsworth and Brooks/Cole, Computer Science Series, Pacific Grove, California.
Birnbaum BA, Noz ME, Chapnick JV, Sanger JJ, Megibow AJ, Maguire GQ Jr, Weinreb JC, Kaminer EM, Kramer EL (1991) Hepatic hemangiomas: diagnosis with fusion of MR, CT, and Tc-99m-labeled red blood cell SPECT images. Radiology 181:469–474.
Eary JF, Appelbaum FL, Durack L, Brown P (1989) Preliminary validation of the opposing view method for quantitative gamma camera imaging. Med Phys 16:382–387.
Fleming JS (1979) A technique for the absolute measurement of activity using a gamma camera and computer. Phys Med Biol 24:176–180.
Hammond ND, Moldofsky PJ, Beardsley MR, Mulhern CB Jr (1984) External imaging techniques for quantitation of distribution of I-131 F(ab′)2 fragments of monoclonal antibody in humans. Med Phys 11:778–783.
Kaminer EA, Noz ME, Sanger JJ, Maguire GQ Jr (1990) Experience with adding a graphical user interface to an existing image processing toolkit. In: Arenson LA, Friedenberg RM (eds) SCAR 90, computer applications to assist radiology. Symposium Foundation, Carlsbad, California, pp 610–617.
Macey DJ, De Nardo GL, De Nardo SJ (1988) Investigation of planar gamma camera methods for the absolute quantitation of radionuclide content of the liver or spleen of an abdominal phantom. J Nucl Med 29:845.
Maguire GQ Jr, Noz ME (1989) Image formats: five years after the APPM standard format for digital image interchange. Med Phys 16:818–823.
Noz ME, Maguire GQ Jr (1988) QSH: a minimal but highly portable image display and handling toolkit. Comput Meth Prog Biomed 27:229–240.
Watson EE, Stabin M, Bolch WE (1984) MIRDOSE. Oak Ridge Associated Universities, Version 2, Oak Ridge, Tennessee.
Zanzonico PB, Sgouros G, Strauss A, Bigler RE (1988) Treatment planning for monoclonal antibody therapy: quantitative planar imaging and its validation using an anthropomorphic phantom. Nucl Med 29:845.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Noz, M.E., Kramer, E.L., Maguire, G.Q. et al. An integrated approach to biodistribution radiation absorbed dose estimates. Eur J Nucl Med 20, 165–169 (1993). https://doi.org/10.1007/BF00168878
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00168878